Erdheim-Chester Disease of the Central Nervous System: New Manifestations of a Rare Disease

ECD is a rare non-Langerhans-cell histiocytosis, which can involve the CNS; therefore, CNS imaging findings have been described in only a small number of patients. To gain additional insight into the CNS manifestations of ECD, we reviewed the findings on imaging of the brain, head and neck, and spin...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2011-12, Vol.32 (11), p.2126-2131
Main Authors: SEDRAK, P, KETONEN, L, HOU, P, GUHA-THAKURTA, N, WILLIAMS, M. D, KURZROCK, R, DEBNAM, J. M
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Brain
Brain Diseases - diagnosis
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diagnostic Imaging - methods
Erdheim-Chester Disease - diagnosis
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Maxillofacial Abnormalities - diagnosis
Medical sciences
Middle Aged
Nervous system
Neurology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Rare Diseases
Spinal Diseases - diagnosis
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Summary:ECD is a rare non-Langerhans-cell histiocytosis, which can involve the CNS; therefore, CNS imaging findings have been described in only a small number of patients. To gain additional insight into the CNS manifestations of ECD, we reviewed the findings on imaging of the brain, head and neck, and spine in patients with ECD who presented to our institution. Here, we illustrate manifestations that have not, to our knowledge, been previously described. CT, MR imaging, and PET/CT studies of the brain, maxillofacial region, and spine were reviewed in 11 patients with ECD. Four new manifestations of ECD were present, including the following: a stellate appearance of intracranial extra-axial lesions, ependymal enhancement along the lateral ventricle with deep linear extension to the lentiform nucleus, irregular enhancement in the pons, and diffuse involvement of the vertebral column on PET/CT. ECD has a variety of imaging appearances in the CNS, including new manifestations described herein. Neuroradiologists should be aware of these manifestations to avoid mistaking them for other disease processes.
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.a2707