Apparent Diffusion Coefficient with Higher b-Value Correlates Better with Viable Cell Count Quantified from the Cavity of Brain Abscess

DWI by using higher b-values provides tissue diffusivity with less T2 shinethrough effect. VCD in the abscess cavity correlates with ADC values. The purpose of this study was to investigate which b-value-derived ADC correlates better with VCD. Thirty patients with brain abscess underwent conventiona...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2011-12, Vol.32 (11), p.2120-2125
Main Authors: TOMAR, V, YADAV, A, RATHORE, R. K. S, VERMA, S, AWASTHI, R, BHARADWAJ, V, OJHA, B. K, PRASAD, K. N, GUPTA, R. K
Format: Article
Language:English
Subjects:
Adolescent
Adult
Algorithms
Biological and medical sciences
Brain
Brain - pathology
Brain Abscess - pathology
Cell Count - methods
Cell Survival
Child
Diffusion Magnetic Resonance Imaging - methods
Female
Fundamental and applied biological sciences. Psychology
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Nervous system
Perception
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
Vision
Young Adult
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Summary:DWI by using higher b-values provides tissue diffusivity with less T2 shinethrough effect. VCD in the abscess cavity correlates with ADC values. The purpose of this study was to investigate which b-value-derived ADC correlates better with VCD. Thirty patients with brain abscess underwent conventional MR imaging and DWI with b = 1000, 2000, and 3000 s/mm(2) on a 3T MR imaging scanner. ADC values were quantified by placing regions of interest inside the abscess cavity in all sections where the lesion was apparent on coregistered ADC maps derived from different b-values. VCD was measured on pus aspirated. An increase in b-value was associated with a decrease in ADC values in normal parenchyma as well as in the abscess cavity. The most significant negative correlation of VCD was observed with b = 3000 s/mm(2) (r = -0.98, P = .01). VCD in the abscess cavity can be best assessed at b = 3000 s/mm(2) secondary to the reduction in the T2 shinethrough effect. DWI with b = 3000 s/mm(2) is of promising value in the assessment of the therapeutic response of brain abscess.
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A2674