Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape

Effects of blood flow modification by flow diverters are observed to lead often to aneurysm thrombosis and reverse remodeling. For this process, to further understand the potential roles of intra-aneurysmal blood pressure changes and aneurysm morphologies, 23 patients were studied by numeric simulat...

Full description

Saved in:
Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2013-04, Vol.34 (4), p.816-822
Main Authors: Larrabide, I, Aguilar, M L, Morales, H G, Geers, A J, Kulcsár, Z, Rüfenacht, D, Frangi, A F
Format: Article
Language:English
Subjects:
Blood Flow Velocity - physiology
Blood Pressure - physiology
Cerebrovascular Circulation - physiology
Computer Simulation
Databases, Factual
Endovascular Procedures
Hemodynamics - physiology
Humans
Interventional
Intracranial Aneurysm - classification
Intracranial Aneurysm - physiopathology
Intracranial Aneurysm - therapy
Models, Cardiovascular
Thrombosis - physiopathology
Vascular Resistance - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Effects of blood flow modification by flow diverters are observed to lead often to aneurysm thrombosis and reverse remodeling. For this process, to further understand the potential roles of intra-aneurysmal blood pressure changes and aneurysm morphologies, 23 patients were studied by numeric simulation. 3D imaging of aneurysms of different sizes and shapes, all located at the supraclinoid segment of the ICA (n=23), was prepared for CFD simulations. Hemodynamic variables were calculated for conditions before and after virtual FD implantation, reconstituting a vessel wall scaffold across the aneurysm neck. WSS, velocity, residence time, turnover time, and intra-aneurysmal pressure were assessed statistically. After placement of FDs, significant reductions inside the aneurysm were observed for most hemodynamic variables (P
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.a3288