Quantitative Evaluation of C-Arm CT Cerebral Blood Volume in a Canine Model of Ischemic Stroke

• Published in: American journal of neuroradiology : AJNR 2012-02, Vol.33 (2), p.353-358
• Main Authors: VAN DER BOM, I. M. J, MEHRA, M, WALVICK, R. P, CHUEH, J.-Y, GOUNIS, M. J
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Blood Volume; Brain Ischemia - diagnostic imaging; Brain Ischemia - physiopathology; Cardiovascular system; Disease Models, Animal; Dogs; Interventional; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Nervous system; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Stroke - diagnostic imaging; Stroke - physiopathology; Tomography, X-Ray Computed
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/ajnr.a2944

Previous studies have shown the feasibility of assessing qualitative CBV measurements in the angiography suite by using FPD-CBCT systems. We have investigated the correlation of FPD-CBCT CBV lesion volumes to the infarct volume. Unilateral strokes were created in 7 adult dogs. MR imaging and FPD-CBCT data were obtained after MCA occlusion. FPD-CBCT CBV and ADC maps were generated for all subjects. The animals were sacrificed immediately following the last imaging study to measure infarct volume on histology. The reliability of FPD-CBCT-based lesion volume measurements was compared with those measured histologically by using regression and Bland-Altman analysis. The best correlation (R(2) = 0.72) between lesion volumes assessed with FPD-CBCT and histology was established with a threshold of mean healthy CBV - 2.5 × SD. These results were inferior to the correlation of lesion volumes measured with ADC and histology (R(2) = 0.99). Bland-Altman analysis showed that the agreement of ADC-derived lesion volumes with histology was superior to the agreement of FPD-CBCT-derived lesion volumes with histology. We correlated FPD-CBCT measurements of CBV and MR ADC lesion volumes with histologically assessed infarct volume. As expected, ADC is a very accurate and precise method for determining the extent of infarction. FPD-CBCT CBV lesion volumes are correlated to the size of the infarct. Improvement of FPD-CBCT image quality provides an opportunity to establish quantitative CBV measurement in the angiography suite.