A Novel Method of Thrombus Preparation for Use in a Swine Model for Evaluation of Thrombectomy Devices

We report the development of a novel technique of thrombus preparation for use in a swine model for evaluation of thrombectomy devices. The experimental thrombus prepared using plain sedimentation showed mechanical stability due to its solid fibrin-rich component. The thrombus also showed histologic...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2010-10, Vol.31 (9), p.1741-1743
Main Authors: KAN, I, YUKI, I, MURAYAMA, Y, VINUELA, F. A, KIM, R. H, VINTERS, H. V, VINUELA, F
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
Biological and medical sciences
Disease Models, Animal
Equipment Failure Analysis - instrumentation
Equipment Failure Analysis - methods
Humans
Interventional
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Nervous system
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Schizophrenia
Swine
Thrombectomy - instrumentation
Thrombosis - physiopathology
Thrombosis - surgery
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Summary:We report the development of a novel technique of thrombus preparation for use in a swine model for evaluation of thrombectomy devices. The experimental thrombus prepared using plain sedimentation showed mechanical stability due to its solid fibrin-rich component. The thrombus also showed histologic similarity to the typical thromboemboli recovered from patients with stroke in the course of therapeutic thrombectomy. This new technique may be beneficial for preclinical evaluation of thrombectomy devices.
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A1991