Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease

• Published in: American journal of neuroradiology : AJNR 2011-04, Vol.32 (4), p.677-681
• Main Authors: WANG, J, YOU, H, LIU, J.-F, NI, D.-F, ZHANG, Z.-X, GUAN, J
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Atrophy; Biological and medical sciences; Brain; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Echo-Planar Imaging; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nervous system; Neurology; Olfaction Disorders - pathology; Olfaction Disorders - physiopathology; Olfactory Bulb - pathology; Olfactory Bulb - physiology; Olfactory Pathways - pathology; Olfactory Pathways - physiology; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Sensory Thresholds - physiology; Smell - physiology
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/ajnr.A2350

Olfactory dysfunction is commonly associated with IPD. We here report the association of OB volume and OS depth with olfactory function in patients with PD. Morphometric analyses by using MR imaging and the Japanese T&T olfactometer threshold test were used to evaluate olfactory structure and function in 29 patients with PD and 29 age- and sex-matched healthy controls. The olfactory recognition thresholds were significantly higher in patients with PD than in healthy controls (3.82 ± 1.25 versus 0.45 ± 0.65, P