Neuroimaging Features of Neurodegeneration with Brain Iron Accumulation

NBIA characterizes a class of neurodegenerative diseases that feature a prominent extrapyramidal movement disorder, intellectual deterioration, and a characteristic deposition of iron in the basal ganglia. The diagnosis of NBIA is made on the basis of the combination of representative clinical featu...

Full description

Saved in:
Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2012-03, Vol.33 (3), p.407-414
Main Authors: KRUER, M. C, BODDAERT, N, SCHNEIDER, S. A, HOULDEN, H, BHATIA, K. P, GREGORY, A, ANDERSON, J. C, ROONEY, W. D, HOGARTH, P, HAYFLICK, S. J
Format: Article
Language:English
Subjects:
Algorithms
Basal ganglia
Biological and medical sciences
Brain - diagnostic imaging
Brain - pathology
Brain Diseases, Metabolic - complications
Brain Diseases, Metabolic - diagnosis
Computed tomography
Fundamental and applied biological sciences. Psychology
Genetic screening
Human
Humans
Image Enhancement - methods
Investigative techniques, diagnostic techniques (general aspects)
Iron
Iron Overload - complications
Iron Overload - diagnosis
Learning
Learning. Memory
Magnetic resonance imaging
Medical sciences
Movement disorders
Nervous system
Neurodegenerative diseases
Neurodegenerative Diseases - complications
Neurodegenerative Diseases - diagnosis
Neuroimaging
Neuroimaging - methods
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiography
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:NBIA characterizes a class of neurodegenerative diseases that feature a prominent extrapyramidal movement disorder, intellectual deterioration, and a characteristic deposition of iron in the basal ganglia. The diagnosis of NBIA is made on the basis of the combination of representative clinical features along with MR imaging evidence of iron accumulation. In many cases, confirmatory molecular genetic testing is now available as well. A number of new subtypes of NBIA have recently been described, with distinct neuroradiologic and clinical features. This article outlines the known subtypes of NBIA, delineates their clinical and radiographic features, and suggests an algorithm for evaluation.
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A2677