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Effects of Nicotine Metabolic Rate on Withdrawal Symptoms and Response to Cigarette Smoking After Abstinence

This study investigated the influence of the rate of nicotine metabolism, as indicated by the nicotine metabolite ratio (NMR), on tobacco dependence. We stratified 136 smokers on the basis of saliva NMR as fast (n = 65) and slow (n = 71) metabolizers. Two “loading cigarettes” were smoked after overn...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2019-03, Vol.105 (3), p.641-651
Main Authors: Liakoni, Evangelia, Edwards, Kathryn C., St. Helen, Gideon, Nardone, Natalie, Dempsey, Delia A., Tyndale, Rachel F., Benowitz, Neal L.
Format: Article
Language:English
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Summary:This study investigated the influence of the rate of nicotine metabolism, as indicated by the nicotine metabolite ratio (NMR), on tobacco dependence. We stratified 136 smokers on the basis of saliva NMR as fast (n = 65) and slow (n = 71) metabolizers. Two “loading cigarettes” were smoked after overnight, and a “reward cigarette” was smoked after 6 hours of daytime, abstinence. Blood nicotine concentrations, expired carbon monoxide, withdrawal/craving, and reward questionnaires were collected before/after smoking and during daytime abstinence. Compared with slow metabolizers, fast metabolizers had a shorter nicotine elimination half‐life (P 
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.1238