Detection of Intratumoral Calcification in Oligodendrogliomas by Susceptibility-Weighted MR Imaging

• Published in: American journal of neuroradiology : AJNR 2012-05, Vol.33 (5), p.858-864
• Main Authors: ZULFIQAR, M, DUMRONGPISUTIKUL, N, INTRAPIROMKUL, J, YOUSEM, D. M
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Biological and medical sciences; Brain; Brain Neoplasms - complications; Brain Neoplasms - pathology; Calcification; Calcinosis - complications; Calcinosis - pathology; Computed tomography; Data processing; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Hemorrhage; Humans; Investigative techniques, diagnostic techniques (general aspects); Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; Nervous system; Nervous system (semeiology, syndromes); Neuroimaging; Neurology; oligodendroglioma; Oligodendroglioma - complications; Oligodendroglioma - pathology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Reproducibility of Results; Sensitivity and Specificity; Statistics
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/ajnr.a2862

SWI is a unique pulse sequence sensitive to both hemorrhage and calcification. Our aim was to retrospectively assess the ability of SWI to detect intratumoral calcification in ODs compared with conventional MR imaging. Using CT as criterion standard, the MR imaging findings from 71 patients (33 males, 38 females; mean age, 42.5 years) with pathologically proved OD were retrospectively evaluated. We classified the MR imaging data into SWI data (MRSWI) and traditional pulse sequences (MRnoSWI). The sensitivity and specificity of the MRnoSWI (n = 71) were compared with that of the MRSWI (n = 13) independently and also for matched-paired data (n = 13). The Fisher exact test was applied to the matched-pair data for statistical evaluation. For paired data of MRSWI and MRnoSWI (n = 13), there was significantly increased sensitivity of MRSWI (86%) for the detection of intratumoral calcification in OD compared with the MRnoSWI (14.3%) (P = .015, Fisher exact test) by using CT as the criterion standard. The overall accuracy of MRSWI for the paired data was also significantly greater (P = .048). The specificities were not significantly different (P = .773). The sensitivity of MRSWI (n = 13) was 86%, and for MRnoSWI (n = 71), it was 33.3%. Specificity of MRSWI was 83%, and for MRnoSWI, it was 95%. SWI is better able to detect calcification in ODs than conventional MR imaging pulse sequences.