The high expression of CHD1L and its clinical significance in human solid tumors: A meta-analysis

• Published in: Medicine (Baltimore) 2021-03, Vol.100 (10), p.e24851-e24851
• Main Authors: Zhang, Long, Jiang, Yufen, Jiao, Panpan, Deng, Xiaohong, Xie, Yuancai
• Format: Article
• Language: English
• Subjects: Biomarkers, Tumor - genetics; DNA Helicases - genetics; DNA-Binding Proteins - genetics; Humans; Neoplasm Metastasis; Neoplasms - genetics; Neoplasms - mortality; Neoplasms - pathology; Prognosis; Survival Analysis; Systematic Review and Meta-Analysis; Tumor Burden; Up-Regulation
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000024851

Chromodomain helicase DNA-binding protein 1-like (CHD1L) is an oncogene. It was cloned from 1q21 chromosome region of hepatocellular carcinoma in 1991. CHD1L is up-regulated in many kinds of cancers and is involved in the carcinogenesis and development of tumors. More and more studies have shown that over-expression of CHD1L is associated with poor prognosis of tumors. The purpose of this study was to evaluate the prognostic value of CHD1L in human solid tumors. The key words in the database of PubMed, Web of Science, Embase, Cochrane library, and TCGA were searched for systematic literature retrieval. We collected relevant articles and data about CHD1L and prognosis of cancer and screened them according to the eligible criteria to evaluate the prognostic value of CHD1L in cancer patients. Then Stata SE12.0 software is used to analyze the data. In our meta-analysis, 2720 patients with a total of 15 articles involving multiple types of tumors showed that high expression levels of CHD1L were associated with shorter overall survival (OS) (hazard ratio  = 2.21, 95% confidence interval [CI]: (1.49-3.30)] and (hazard ratio  = 1.16, 95% CI: (1.01-1.32)] in the TCGA database, in addition, the pooled odds ratios (ORs) indicated high expression levels of CHD1L in tumors significantly are associated with TNM stage (OR = 1.61, 95% CI: 1.01-2.55, P