Hypovitaminosis D and the endocrine phenotype of COVID-19

Background Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25O...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine 2021-04, Vol.72 (1), p.1-11
Main Author: Giustina, Andrea
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Coronaviruses
COVID-19
Diabetes
Endocrine Reports from the COVID-19 Frontline
Endocrinology
Humanities and Social Sciences
Humans
Immunomodulation
Internal Medicine
Medicine
Medicine & Public Health
multidisciplinary
Phenotype
Phenotypes
Review
SARS-CoV-2
Science
Vitamin D
Vitamin D Deficiency - complications
Vitamin deficiency
Vitamins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25OHD) in hospitalized patients with COVID-19. Moreover, several studies reported a correlation between 25OHD levels and different clinical outcomes of the disease. Aim Aim of the current review was to approach the topic of vitamin D and COVID-19 from a different perspective summarizing the data which led to the evidence of the existence of an endocrine phenotype of COVID-19. Conclusions This review analyzed in the light of the current knowledge the possibility that several endocrine manifestations of COVID-19 could be holistically interpreted in the context of an inadequate vitamin D status.
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-021-02671-8