Cerebral Hemodynamics in Asymptomatic Patients with Internal Carotid Artery Occlusion: A Dynamic Susceptibility Contrast MR and Transcranial Doppler Study

Perfusion imaging with dynamic susceptibility contrast MR imaging (DSC-MRI) has been used to evaluate hemodynamic status in patients with symptomatic occlusive cerebrovascular disease. The aim of the present study was to determine the hemodynamic changes occurring in asymptomatic patients with unila...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2001-06, Vol.22 (6), p.1062-1067
Main Authors: Apruzzese, Alessio, Silvestrini, Mauro, Floris, Roberto, Vernieri, Fabrizio, Bozzao, Alessandro, Hagberg, Gisela, Caltagirone, Carlo, Masala, Salvatore, Simonetti, Giovanni
Format: Article
Language:English
Subjects:
Angiography, Digital Subtraction
Biological and medical sciences
Blood Flow Velocity - physiology
Blood Volume - physiology
Brain
Brain - blood supply
Carotid Artery, Internal - pathology
Carotid Artery, Internal - physiopathology
Carotid Stenosis - diagnosis
Carotid Stenosis - physiopathology
Collateral Circulation - physiology
Dominance, Cerebral - physiology
Hemodynamics - physiology
Humans
Image Enhancement
Imaging, Three-Dimensional
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Medical sciences
Neurology
Regional Blood Flow - physiology
Sensitivity and Specificity
Ultrasonography, Doppler, Transcranial
Vascular diseases and vascular malformations of the nervous system
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Summary:Perfusion imaging with dynamic susceptibility contrast MR imaging (DSC-MRI) has been used to evaluate hemodynamic status in patients with symptomatic occlusive cerebrovascular disease. The aim of the present study was to determine the hemodynamic changes occurring in asymptomatic patients with unilateral internal carotid artery (ICA) occlusion by use of DSC-MRI with transcranial Doppler (TCD) measurement of the breath-holding index (BHI). Nine patients with asymptomatic unilateral ICA occlusion underwent DSC-MRI and TCD examination. One patient was excluded from final analysis because of severe movement artifacts. On a separate workstation, regional cerebral blood volume (rCBV), regional cerebral blood flow (rCBF), and regional mean time to peak (rMTT) were calculated on the basis of signal decay rate during the passage of gadolinium bolus through the sampled volume in the territory of the middle cerebral artery. TCD-BHI was calculated in all patients. Six healthy subjects underwent the same MR protocol as the patients. Compared with control subjects, patients with unilateral ICA occlusions had hemodynamic changes in the ipsilateral hemisphere: rCBF was significantly lower than in controls (P
ISSN:0195-6108
1936-959X