Clinical Applications of Tumor Volume Measurements for Predicting Outcome in Patients with Squamous Cell Carcinoma of the Upper Aerodigestive Tract

Gross tumor volume (GTV) at the primary site, as derived from pretreatment CT findings, can help predict local control of squamous cell carcinoma at different head and neck subsites after treatment with nonsurgical organ preservation. Local recurrence is more likely with large tumors than with small...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2004-09, Vol.25 (8), p.1425-1432
Main Authors: Mukherji, Suresh K, Schmalfuss, Ilona M, Castelijns, Jonas, Mancuso, Anthony A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Squamous Cell - diagnostic imaging
Carcinoma, Squamous Cell - therapy
Gastrointestinal Neoplasms - diagnostic imaging
Gastrointestinal Neoplasms - therapy
Head and Neck
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Nervous system
Predictive Value of Tests
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiography
Respiratory Tract Neoplasms - diagnostic imaging
Respiratory Tract Neoplasms - therapy
Treatment Outcome
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Summary:Gross tumor volume (GTV) at the primary site, as derived from pretreatment CT findings, can help predict local control of squamous cell carcinoma at different head and neck subsites after treatment with nonsurgical organ preservation. Local recurrence is more likely with large tumors than with small lesions in the same anatomic subsite, and GTV is often more strongly associated with local control than is tumor stage. This review discusses tumor volume calculation-technique, current literature, and potential clinical applications-and aims to help the reader to understand the role of GTV calculations and to integrate this knowledge into clinical practice.
ISSN:0195-6108
1936-959X