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Quantitative functional MR imaging of the visual cortex at 1.5 T as a function of luminance contrast in healthy volunteers and patients with multiple sclerosis
In patients with multiple sclerosis (MS), a few preliminary functional MR (fMR) imaging studies of the visual cortex reveal information about magnitude differences between healthy individuals and patients with MS at only a single luminance level. We therefore investigated whether varying luminance c...
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| Published in: | American journal of neuroradiology : AJNR 2002, Vol.23 (1), p.59-65 |
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| container_title | American journal of neuroradiology : AJNR |
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| creator | FARO, Scott H MOHAMED, Feroze B TRACY, Joseph I ELFONT, Robert M PINUS, Alexander B LUBLIN, Fred D KOENIGSBERG, Robert A CHEN, Cheng Y TSAI, Fong Y |
| description | In patients with multiple sclerosis (MS), a few preliminary functional MR (fMR) imaging studies of the visual cortex reveal information about magnitude differences between healthy individuals and patients with MS at only a single luminance level. We therefore investigated whether varying luminance contrast levels can help uncover subtle changes in fMR imaging characteristics of the visual cortex in healthy volunteers and patients with MS.
Blood oxygenation level-dependent fMR imaging signal changes in the primary visual cortex were examined as a function of luminance contrast at 1.5 T in 10 healthy volunteers and nine patients with MS. Ten axial sections through the calcarine fissure were obtained with an echo-planar T2*-weighted imaging sequence (4000/54/1 [TR/TE/excitation]; field of view, 220 mm; voxel size, 1.72 x 1.72 x 5 mm). The imaging series consisted of an alternating 20-second rest epoch (black screen) with a 20-second activation epoch (flickering checkerboard) repeated six times. Each imaging series used a graded increase of eight luminance contrast levels. A paired t test between rest and activation images was used to analyze significant (P |
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Blood oxygenation level-dependent fMR imaging signal changes in the primary visual cortex were examined as a function of luminance contrast at 1.5 T in 10 healthy volunteers and nine patients with MS. Ten axial sections through the calcarine fissure were obtained with an echo-planar T2*-weighted imaging sequence (4000/54/1 [TR/TE/excitation]; field of view, 220 mm; voxel size, 1.72 x 1.72 x 5 mm). The imaging series consisted of an alternating 20-second rest epoch (black screen) with a 20-second activation epoch (flickering checkerboard) repeated six times. Each imaging series used a graded increase of eight luminance contrast levels. A paired t test between rest and activation images was used to analyze significant (P <.001) contiguous voxels in the region of interest (primary visual cortex).
A progressive increase in fMR imaging activation across all luminance contrast levels in healthy controls and patients with MS was shown. The patients with MS had a significantly lower magnitude in the number of fMR imaging activated voxels at all luminance contrast levels (P <.001). A statistically significant increase in fMR imaging activation (activation threshold) was seen at the second luminance contrast level in controls and at the seventh level in patients with MS.
Quantifiable changes in blood oxygenation level-dependent signal and a progressive increase in activated voxels within the primary visual cortex with increasing luminance contrast were demonstrated at 1.5 T in controls. The patients with MS showed a significant decrease in the number of activated voxels and an increase in activation threshold compared with healthy controls.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>PMID: 11827876</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: American Society of Neuroradiology</publisher><subject>Adult ; Arousal - physiology ; Biological and medical sciences ; Brain ; Female ; Humans ; Image Enhancement ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - physiopathology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Optic Neuritis - diagnosis ; Optic Neuritis - physiopathology ; Oxygen - blood ; Pattern Recognition, Visual - physiology ; Reference Values ; Sensitivity and Specificity ; Visual Cortex - physiopathology ; Visual Pathways - physiopathology</subject><ispartof>American journal of neuroradiology : AJNR, 2002, Vol.23 (1), p.59-65</ispartof><rights>2002 INIST-CNRS</rights><rights>American Saciety of Neuroradiology 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975504/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975504/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13443306$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11827876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FARO, Scott H</creatorcontrib><creatorcontrib>MOHAMED, Feroze B</creatorcontrib><creatorcontrib>TRACY, Joseph I</creatorcontrib><creatorcontrib>ELFONT, Robert M</creatorcontrib><creatorcontrib>PINUS, Alexander B</creatorcontrib><creatorcontrib>LUBLIN, Fred D</creatorcontrib><creatorcontrib>KOENIGSBERG, Robert A</creatorcontrib><creatorcontrib>CHEN, Cheng Y</creatorcontrib><creatorcontrib>TSAI, Fong Y</creatorcontrib><title>Quantitative functional MR imaging of the visual cortex at 1.5 T as a function of luminance contrast in healthy volunteers and patients with multiple sclerosis</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>In patients with multiple sclerosis (MS), a few preliminary functional MR (fMR) imaging studies of the visual cortex reveal information about magnitude differences between healthy individuals and patients with MS at only a single luminance level. We therefore investigated whether varying luminance contrast levels can help uncover subtle changes in fMR imaging characteristics of the visual cortex in healthy volunteers and patients with MS.
Blood oxygenation level-dependent fMR imaging signal changes in the primary visual cortex were examined as a function of luminance contrast at 1.5 T in 10 healthy volunteers and nine patients with MS. Ten axial sections through the calcarine fissure were obtained with an echo-planar T2*-weighted imaging sequence (4000/54/1 [TR/TE/excitation]; field of view, 220 mm; voxel size, 1.72 x 1.72 x 5 mm). The imaging series consisted of an alternating 20-second rest epoch (black screen) with a 20-second activation epoch (flickering checkerboard) repeated six times. Each imaging series used a graded increase of eight luminance contrast levels. A paired t test between rest and activation images was used to analyze significant (P <.001) contiguous voxels in the region of interest (primary visual cortex).
A progressive increase in fMR imaging activation across all luminance contrast levels in healthy controls and patients with MS was shown. The patients with MS had a significantly lower magnitude in the number of fMR imaging activated voxels at all luminance contrast levels (P <.001). A statistically significant increase in fMR imaging activation (activation threshold) was seen at the second luminance contrast level in controls and at the seventh level in patients with MS.
Quantifiable changes in blood oxygenation level-dependent signal and a progressive increase in activated voxels within the primary visual cortex with increasing luminance contrast were demonstrated at 1.5 T in controls. The patients with MS showed a significant decrease in the number of activated voxels and an increase in activation threshold compared with healthy controls.</description><subject>Adult</subject><subject>Arousal - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Female</subject><subject>Humans</subject><subject>Image Enhancement</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Optic Neuritis - diagnosis</subject><subject>Optic Neuritis - physiopathology</subject><subject>Oxygen - blood</subject><subject>Pattern Recognition, Visual - physiology</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Visual Cortex - physiopathology</subject><subject>Visual Pathways - physiopathology</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpVkcFu1TAQRSMEoo_CL6DZwC7IjuM43iChigJSESoqErto4kxejBwnxPaDfk1_ta54FLqaxT1z7-jOo2LHtWhKLfX3x8WOcS3LhrP2pHgWwg_GmNSqelqccN5WqlXNrri5TOijjRjtgWBM3kS7eHTw-SvYGffW72EZIU4EBxtSFsyyRfoNGIG_kXAFGADvF-9Yl2br0RvKqI8bhgjWw0To4nQNh8UlH4m2vOYHWHMw-Rjgl40TzMlFuzqCYBxtS7DhefFkRBfoxXGeFt_O31-dfSwvvnz4dPbuolwrXcVy7PnQN40i0lSrhrWMBiFxHBjjho9s1MqQrnWtKtHXkle6HbBC0UsjmewrcVq8_eO7pn6mwdDd5a5bt1zCdt0taLuHirdTt18OndJKSlZng9dHg235mSjEbrbBkHPoaUmhU7wWUjOewZf_J91H_P1JBl4dAQwG3bjlLm34x4m6FoI14hZakprq</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>FARO, Scott H</creator><creator>MOHAMED, Feroze B</creator><creator>TRACY, Joseph I</creator><creator>ELFONT, Robert M</creator><creator>PINUS, Alexander B</creator><creator>LUBLIN, Fred D</creator><creator>KOENIGSBERG, Robert A</creator><creator>CHEN, Cheng Y</creator><creator>TSAI, Fong Y</creator><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2002</creationdate><title>Quantitative functional MR imaging of the visual cortex at 1.5 T as a function of luminance contrast in healthy volunteers and patients with multiple sclerosis</title><author>FARO, Scott H ; MOHAMED, Feroze B ; TRACY, Joseph I ; ELFONT, Robert M ; PINUS, Alexander B ; LUBLIN, Fred D ; KOENIGSBERG, Robert A ; CHEN, Cheng Y ; TSAI, Fong Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p292t-fb1db667ee9e476080ed35afd001c1f0f97ce9494723b451298da2a3b5c505b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Arousal - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Female</topic><topic>Humans</topic><topic>Image Enhancement</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Optic Neuritis - diagnosis</topic><topic>Optic Neuritis - physiopathology</topic><topic>Oxygen - blood</topic><topic>Pattern Recognition, Visual - physiology</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>Visual Cortex - physiopathology</topic><topic>Visual Pathways - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FARO, Scott H</creatorcontrib><creatorcontrib>MOHAMED, Feroze B</creatorcontrib><creatorcontrib>TRACY, Joseph I</creatorcontrib><creatorcontrib>ELFONT, Robert M</creatorcontrib><creatorcontrib>PINUS, Alexander B</creatorcontrib><creatorcontrib>LUBLIN, Fred D</creatorcontrib><creatorcontrib>KOENIGSBERG, Robert A</creatorcontrib><creatorcontrib>CHEN, Cheng Y</creatorcontrib><creatorcontrib>TSAI, Fong Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FARO, Scott H</au><au>MOHAMED, Feroze B</au><au>TRACY, Joseph I</au><au>ELFONT, Robert M</au><au>PINUS, Alexander B</au><au>LUBLIN, Fred D</au><au>KOENIGSBERG, Robert A</au><au>CHEN, Cheng Y</au><au>TSAI, Fong Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative functional MR imaging of the visual cortex at 1.5 T as a function of luminance contrast in healthy volunteers and patients with multiple sclerosis</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2002</date><risdate>2002</risdate><volume>23</volume><issue>1</issue><spage>59</spage><epage>65</epage><pages>59-65</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><coden>AAJNDL</coden><abstract>In patients with multiple sclerosis (MS), a few preliminary functional MR (fMR) imaging studies of the visual cortex reveal information about magnitude differences between healthy individuals and patients with MS at only a single luminance level. We therefore investigated whether varying luminance contrast levels can help uncover subtle changes in fMR imaging characteristics of the visual cortex in healthy volunteers and patients with MS.
Blood oxygenation level-dependent fMR imaging signal changes in the primary visual cortex were examined as a function of luminance contrast at 1.5 T in 10 healthy volunteers and nine patients with MS. Ten axial sections through the calcarine fissure were obtained with an echo-planar T2*-weighted imaging sequence (4000/54/1 [TR/TE/excitation]; field of view, 220 mm; voxel size, 1.72 x 1.72 x 5 mm). The imaging series consisted of an alternating 20-second rest epoch (black screen) with a 20-second activation epoch (flickering checkerboard) repeated six times. Each imaging series used a graded increase of eight luminance contrast levels. A paired t test between rest and activation images was used to analyze significant (P <.001) contiguous voxels in the region of interest (primary visual cortex).
A progressive increase in fMR imaging activation across all luminance contrast levels in healthy controls and patients with MS was shown. The patients with MS had a significantly lower magnitude in the number of fMR imaging activated voxels at all luminance contrast levels (P <.001). A statistically significant increase in fMR imaging activation (activation threshold) was seen at the second luminance contrast level in controls and at the seventh level in patients with MS.
Quantifiable changes in blood oxygenation level-dependent signal and a progressive increase in activated voxels within the primary visual cortex with increasing luminance contrast were demonstrated at 1.5 T in controls. The patients with MS showed a significant decrease in the number of activated voxels and an increase in activation threshold compared with healthy controls.</abstract><cop>Oak Brook, IL</cop><pub>American Society of Neuroradiology</pub><pmid>11827876</pmid><tpages>7</tpages></addata></record> |
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| ispartof | American journal of neuroradiology : AJNR, 2002, Vol.23 (1), p.59-65 |
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| subjects | Adult Arousal - physiology Biological and medical sciences Brain Female Humans Image Enhancement Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Multiple Sclerosis - diagnosis Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Optic Neuritis - diagnosis Optic Neuritis - physiopathology Oxygen - blood Pattern Recognition, Visual - physiology Reference Values Sensitivity and Specificity Visual Cortex - physiopathology Visual Pathways - physiopathology |
| title | Quantitative functional MR imaging of the visual cortex at 1.5 T as a function of luminance contrast in healthy volunteers and patients with multiple sclerosis |
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