PDMAEMA/Polyester Miktopolymers: Synthesis via In-Out Approach, Physicochemical Characterization and Enzymatic Degradation

Synthesis, physicochemical characterization, and the enzymatic degradation of the amphiphilic miktoarm star-shaped polymers is reported herein. First, star-shaped macroinitiators, based on '-dimethylaminoethyl methacrylate (DMAEMA) and glycerol dimethacrylate (GDMA) ((PDMAEMA) -PGDMA), were syn...

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Bibliographic Details
Published in:Materials 2021-03, Vol.14 (5), p.1277
Main Authors: Kupczak, Maria, Mielańczyk, Anna, Neugebauer, Dorota
Format: Article
Language:English
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Summary:Synthesis, physicochemical characterization, and the enzymatic degradation of the amphiphilic miktoarm star-shaped polymers is reported herein. First, star-shaped macroinitiators, based on '-dimethylaminoethyl methacrylate (DMAEMA) and glycerol dimethacrylate (GDMA) ((PDMAEMA) -PGDMA), were synthesized. Due to the presence of hydroxyl groups in the macroinitiator core, polyesters such as poly(ɛ-caprolactone) (P(ɛ-CL)), polylactide (PLA) and poly(lactide- -glycolide) (PLGA) were synthesized using ring opening polymerization (ROP). Comprehensive degradation studies on enzymatic degradation, using a lipase from , were performed. Enzymatic degradation was monitored by weight measurements and nuclear magnetic resonance spectroscopy ( H NMR). The fastest degradation rate was observed for the polymer with the lowest molecular weight. Amphiphilic miktopolymers may find application as biomaterials for long- or mid-term period drug-delivery systems.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma14051277