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Multi-Section CT Angiography for Detection of Cerebral Aneurysms
Multi-section CT has great potential for use in vascular studies. Our purpose was to determine the accuracy of multi-section CT angiography in detecting cerebral aneurysms compared with digital subtraction angiography or surgery. One hundred consecutive patients who underwent multi-section CT angiog...
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| Published in: | American Journal of Neuroradiology 2004-10, Vol.25 (9), p.1485-1492 |
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| container_title | American Journal of Neuroradiology |
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| creator | Teksam, Mehmet McKinney, Alexander Casey, Sean Asis, Martin Kieffer, Stephen Truwit, Charles L |
| description | Multi-section CT has great potential for use in vascular studies. Our purpose was to determine the accuracy of multi-section CT angiography in detecting cerebral aneurysms compared with digital subtraction angiography or surgery.
One hundred consecutive patients who underwent multi-section CT angiography and either digital subtraction angiography or surgery were included in the study. Multi-section CT angiography and digital subtraction angiography results were evaluated independently by different neuroradiologists who performed aneurysm detection, quantitation, and characterization by using 2D multiplanar reconstructions, 3D maximum intensity projection, and volume-rendered techniques.
When using intra-arterial digital subtraction angiography or surgery, 113 aneurysms (true positives and false negatives) were detected in 83 of the 100 patients. A total of 106 aneurysms (true positives) were confirmed by using digital subtraction angiography or surgery, or both. Seven aneurysms were missed when using multi-section CT angiography. Eight aneurysms were not confirmed by digital subtraction angiography and were considered to be false positive evaluations. The sensitivity for detecting aneurysms < 4 mm, 4 to 10 mm, and > 10 mm on a per-aneurysm basis was 0.84 (95% confidence interval: 0.72, 0.92), 0.97 (95% confidence interval: 0.91, 0.99), and 1.00 (95% confidence interval: 0.88, 1.00), respectively. The sensitivity, specificity, and accuracy of multi-section CT angiography for detecting aneurysms on a per-patient basis were 0.99 (95% confidence interval: 0.96, 1.00), 0.88 (95% confidence interval: 0.69, 0.94), and 0.98 (95% confidence interval: 0.95, 1.00), respectively.
Multi-section CT angiography has a high sensitivity in detecting aneurysms (especially aneurysms > 3 mm). However, CT angiography is currently not sensitive enough to replace digital subtraction angiography. |
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One hundred consecutive patients who underwent multi-section CT angiography and either digital subtraction angiography or surgery were included in the study. Multi-section CT angiography and digital subtraction angiography results were evaluated independently by different neuroradiologists who performed aneurysm detection, quantitation, and characterization by using 2D multiplanar reconstructions, 3D maximum intensity projection, and volume-rendered techniques.
When using intra-arterial digital subtraction angiography or surgery, 113 aneurysms (true positives and false negatives) were detected in 83 of the 100 patients. A total of 106 aneurysms (true positives) were confirmed by using digital subtraction angiography or surgery, or both. Seven aneurysms were missed when using multi-section CT angiography. Eight aneurysms were not confirmed by digital subtraction angiography and were considered to be false positive evaluations. The sensitivity for detecting aneurysms < 4 mm, 4 to 10 mm, and > 10 mm on a per-aneurysm basis was 0.84 (95% confidence interval: 0.72, 0.92), 0.97 (95% confidence interval: 0.91, 0.99), and 1.00 (95% confidence interval: 0.88, 1.00), respectively. The sensitivity, specificity, and accuracy of multi-section CT angiography for detecting aneurysms on a per-patient basis were 0.99 (95% confidence interval: 0.96, 1.00), 0.88 (95% confidence interval: 0.69, 0.94), and 0.98 (95% confidence interval: 0.95, 1.00), respectively.
Multi-section CT angiography has a high sensitivity in detecting aneurysms (especially aneurysms > 3 mm). However, CT angiography is currently not sensitive enough to replace digital subtraction angiography.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>EISSN: 1432-1920</identifier><identifier>PMID: 15502126</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: Am Soc Neuroradiology</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aged ; Angiography, Digital Subtraction ; Biological and medical sciences ; Brain ; Cardiovascular system ; Cerebral Angiography ; Confidence Intervals ; Female ; Humans ; Intracranial Aneurysm - diagnostic imaging ; Intracranial Aneurysm - surgery ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Mood disorders ; Nervous system ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Retrospective Studies ; Sensitivity and Specificity ; Subarachnoid Hemorrhage - diagnostic imaging ; Subarachnoid Hemorrhage - surgery ; Tomography, Spiral Computed</subject><ispartof>American Journal of Neuroradiology, 2004-10, Vol.25 (9), p.1485-1492</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Society of Neuroradiology</rights><rights>Copyright © American Society of Neuroradiology 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976395/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976395/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16215256$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15502126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teksam, Mehmet</creatorcontrib><creatorcontrib>McKinney, Alexander</creatorcontrib><creatorcontrib>Casey, Sean</creatorcontrib><creatorcontrib>Asis, Martin</creatorcontrib><creatorcontrib>Kieffer, Stephen</creatorcontrib><creatorcontrib>Truwit, Charles L</creatorcontrib><title>Multi-Section CT Angiography for Detection of Cerebral Aneurysms</title><title>American Journal of Neuroradiology</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>Multi-section CT has great potential for use in vascular studies. Our purpose was to determine the accuracy of multi-section CT angiography in detecting cerebral aneurysms compared with digital subtraction angiography or surgery.
One hundred consecutive patients who underwent multi-section CT angiography and either digital subtraction angiography or surgery were included in the study. Multi-section CT angiography and digital subtraction angiography results were evaluated independently by different neuroradiologists who performed aneurysm detection, quantitation, and characterization by using 2D multiplanar reconstructions, 3D maximum intensity projection, and volume-rendered techniques.
When using intra-arterial digital subtraction angiography or surgery, 113 aneurysms (true positives and false negatives) were detected in 83 of the 100 patients. A total of 106 aneurysms (true positives) were confirmed by using digital subtraction angiography or surgery, or both. Seven aneurysms were missed when using multi-section CT angiography. Eight aneurysms were not confirmed by digital subtraction angiography and were considered to be false positive evaluations. The sensitivity for detecting aneurysms < 4 mm, 4 to 10 mm, and > 10 mm on a per-aneurysm basis was 0.84 (95% confidence interval: 0.72, 0.92), 0.97 (95% confidence interval: 0.91, 0.99), and 1.00 (95% confidence interval: 0.88, 1.00), respectively. The sensitivity, specificity, and accuracy of multi-section CT angiography for detecting aneurysms on a per-patient basis were 0.99 (95% confidence interval: 0.96, 1.00), 0.88 (95% confidence interval: 0.69, 0.94), and 0.98 (95% confidence interval: 0.95, 1.00), respectively.
Multi-section CT angiography has a high sensitivity in detecting aneurysms (especially aneurysms > 3 mm). However, CT angiography is currently not sensitive enough to replace digital subtraction angiography.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Angiography, Digital Subtraction</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cardiovascular system</subject><subject>Cerebral Angiography</subject><subject>Confidence Intervals</subject><subject>Female</subject><subject>Humans</subject><subject>Intracranial Aneurysm - diagnostic imaging</subject><subject>Intracranial Aneurysm - surgery</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Nervous system</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Subarachnoid Hemorrhage - diagnostic imaging</subject><subject>Subarachnoid Hemorrhage - surgery</subject><subject>Tomography, Spiral Computed</subject><issn>0195-6108</issn><issn>1936-959X</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLxDAUhYMozvj4C9KN7gp5TNJkIw7jE0ZcOIK7kGTSNtI2Y9Ja5t9bsDq6cnUW5-O7h7sHpkgQlgoqXvfBFCJBU4Ygn4CjGN8ghFRk-BBMEKUQI8ym4Oqxq1qXPlvTOt8ki1Uybwrni6A25TbJfUiubTuWPk8WNlgdVDVQtgvbWMcTcJCrKtrTMY_By-3NanGfLp_uHhbzZVoSytpUc6IshJpnODeG4Zk2bAioCc_XnCmak0wQSFlGs3xmrUFk2Kg4IcgypDU5Bpdf3k2na7s2tmmHHXITXK3CVnrl5N-mcaUs_IfMRMaIoIPgYhQE_97Z2MraRWOrSjXWd1EyJgQnNPsXxBBThKAYwLPfk362fH93AM5HQEWjqjyoxri44xhGFFO2u1i6ouxdsDLWqqoGLZJ932MqhUQzTsknepORcQ</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Teksam, Mehmet</creator><creator>McKinney, Alexander</creator><creator>Casey, Sean</creator><creator>Asis, Martin</creator><creator>Kieffer, Stephen</creator><creator>Truwit, Charles L</creator><general>Am Soc Neuroradiology</general><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20041001</creationdate><title>Multi-Section CT Angiography for Detection of Cerebral Aneurysms</title><author>Teksam, Mehmet ; McKinney, Alexander ; Casey, Sean ; Asis, Martin ; Kieffer, Stephen ; Truwit, Charles L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h356t-b83ae00b872fcc624bc6c620b38fd86a5f3793056757f4eec13550a8331e61bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Angiography, Digital Subtraction</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cardiovascular system</topic><topic>Cerebral Angiography</topic><topic>Confidence Intervals</topic><topic>Female</topic><topic>Humans</topic><topic>Intracranial Aneurysm - diagnostic imaging</topic><topic>Intracranial Aneurysm - surgery</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Nervous system</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Subarachnoid Hemorrhage - diagnostic imaging</topic><topic>Subarachnoid Hemorrhage - surgery</topic><topic>Tomography, Spiral Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teksam, Mehmet</creatorcontrib><creatorcontrib>McKinney, Alexander</creatorcontrib><creatorcontrib>Casey, Sean</creatorcontrib><creatorcontrib>Asis, Martin</creatorcontrib><creatorcontrib>Kieffer, Stephen</creatorcontrib><creatorcontrib>Truwit, Charles L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American Journal of Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teksam, Mehmet</au><au>McKinney, Alexander</au><au>Casey, Sean</au><au>Asis, Martin</au><au>Kieffer, Stephen</au><au>Truwit, Charles L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multi-Section CT Angiography for Detection of Cerebral Aneurysms</atitle><jtitle>American Journal of Neuroradiology</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>25</volume><issue>9</issue><spage>1485</spage><epage>1492</epage><pages>1485-1492</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><eissn>1432-1920</eissn><coden>AAJNDL</coden><abstract>Multi-section CT has great potential for use in vascular studies. Our purpose was to determine the accuracy of multi-section CT angiography in detecting cerebral aneurysms compared with digital subtraction angiography or surgery.
One hundred consecutive patients who underwent multi-section CT angiography and either digital subtraction angiography or surgery were included in the study. Multi-section CT angiography and digital subtraction angiography results were evaluated independently by different neuroradiologists who performed aneurysm detection, quantitation, and characterization by using 2D multiplanar reconstructions, 3D maximum intensity projection, and volume-rendered techniques.
When using intra-arterial digital subtraction angiography or surgery, 113 aneurysms (true positives and false negatives) were detected in 83 of the 100 patients. A total of 106 aneurysms (true positives) were confirmed by using digital subtraction angiography or surgery, or both. Seven aneurysms were missed when using multi-section CT angiography. Eight aneurysms were not confirmed by digital subtraction angiography and were considered to be false positive evaluations. The sensitivity for detecting aneurysms < 4 mm, 4 to 10 mm, and > 10 mm on a per-aneurysm basis was 0.84 (95% confidence interval: 0.72, 0.92), 0.97 (95% confidence interval: 0.91, 0.99), and 1.00 (95% confidence interval: 0.88, 1.00), respectively. The sensitivity, specificity, and accuracy of multi-section CT angiography for detecting aneurysms on a per-patient basis were 0.99 (95% confidence interval: 0.96, 1.00), 0.88 (95% confidence interval: 0.69, 0.94), and 0.98 (95% confidence interval: 0.95, 1.00), respectively.
Multi-section CT angiography has a high sensitivity in detecting aneurysms (especially aneurysms > 3 mm). However, CT angiography is currently not sensitive enough to replace digital subtraction angiography.</abstract><cop>Oak Brook, IL</cop><pub>Am Soc Neuroradiology</pub><pmid>15502126</pmid><tpages>8</tpages></addata></record> |
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| ispartof | American Journal of Neuroradiology, 2004-10, Vol.25 (9), p.1485-1492 |
| issn | 0195-6108 1936-959X 1432-1920 |
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| source | PubMed Central (Open Access); Springer Link |
| subjects | Adult Adult and adolescent clinical studies Aged Angiography, Digital Subtraction Biological and medical sciences Brain Cardiovascular system Cerebral Angiography Confidence Intervals Female Humans Intracranial Aneurysm - diagnostic imaging Intracranial Aneurysm - surgery Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Miscellaneous Mood disorders Nervous system Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiodiagnosis. Nmr imagery. Nmr spectrometry Retrospective Studies Sensitivity and Specificity Subarachnoid Hemorrhage - diagnostic imaging Subarachnoid Hemorrhage - surgery Tomography, Spiral Computed |
| title | Multi-Section CT Angiography for Detection of Cerebral Aneurysms |
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