Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer

Ultrasound and optical imagers are used widely in a variety of biological and medical applications. In particular, multimodal implementations combining light and sound have been actively investigated to improve imaging quality. However, the integration of optical sensors with opaque ultrasound trans...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2021-03, Vol.118 (11), p.1-12
Main Authors: Park, Jeongwoo, Park, Byullee, Kim, Tae Yeong, Jung, Sungjin, Choi, Woo June, Ahn, Joongho, Yoon, Dong Hee, Kim, Jeongho, Jeon, Seungwan, Lee, Donghyun, Yong, Uijung, Jang, Jinah, Kim, Won Jong, Kim, Hong Kyun, Jeong, Unyong, Kim, Hyung Ham, Kim, Chulhong
Format: Article
Language:English
Subjects:
Biological Sciences
Cataracts
Coherence
Cornea
Fluorescence
Form factors
Inflammation
Integration
Mammary gland
Medical imaging
Nanorods
Ophthalmology
Optical measuring instruments
Physical Sciences
Transducers
Tumors
Ultrasonic imaging
Ultrasound
Vascularization
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Summary:Ultrasound and optical imagers are used widely in a variety of biological and medical applications. In particular, multimodal implementations combining light and sound have been actively investigated to improve imaging quality. However, the integration of optical sensors with opaque ultrasound transducers suffers from low signal-to-noise ratios, high complexity, and bulky form factors, significantly limiting its applications. Here, we demonstrate a quadruple fusion imaging system using a spherically focused transparent ultrasound transducer that enables seamless integration of ultrasound imaging with photoacoustic imaging, optical coherence tomography, and fluorescence imaging. As a first application, we comprehensively monitored multiparametric responses to chemical and suture injuries in rats’ eyes in vivo, such as corneal neovascularization, structural changes, cataracts, and inflammation. As a second application, we successfully performed multimodal imaging of tumors in vivo, visualizing melanomas without using labels and visualizing 4T1 mammary carcinomas using PEGylated gold nanorods. We strongly believe that the seamlessly integrated multimodal system can be used not only in ophthalmology and oncology but also in other healthcare applications with broad impact and interest.
ISSN:0027-8424
1091-6490
1091-6490
DOI:10.1073/pnas.1920879118