Interrelationship of Neurogenic Obesity and Chronic Neuropathic Pain in Persons With Spinal Cord Injury

The prevalence of obesity and of neuropathic pain are both estimated at above 50% in the population of people with chronic spinal cord injury (SCI). These secondary consequences of SCI have significant negative impact on physical functioning, activities of daily living, and quality of life. Investig...

Full description

Saved in:
Bibliographic Details
Published in:Topics in spinal cord injury rehabilitation 2021, Vol.27 (1), p.75-83
Main Authors: Felix, Elizabeth R, Gater, Jr, David R
Format: Article
Language:English
Subjects:
Body fat
Body mass index
Chronic pain
Cytokines
Gastrointestinal surgery
Humans
Metabolic syndrome
Metabolic Syndrome - etiology
Nervous system
Neuralgia - etiology
Neuralgia - metabolism
Obesity
Obesity - complications
Overweight
Pain
Risk Factors
Spinal cord injuries
Spinal Cord Injuries - complications
Weight control
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The prevalence of obesity and of neuropathic pain are both estimated at above 50% in the population of people with chronic spinal cord injury (SCI). These secondary consequences of SCI have significant negative impact on physical functioning, activities of daily living, and quality of life. Investigations of relationships between weight or body composition and chronic neuropathic pain in people with SCI are lacking, but investigations in non-SCI cohorts suggest an association between obesity and the presence and severity of neuropathic pain conditions. In the present article, we present a review of the literature linking obesity and neuropathic pain and summarize findings suggesting that metabolic syndrome and chronic, systemic inflammation due to excess adiposity increase the risk for neuropathic pain after an SCI.
ISSN:1082-0744
1945-5763
1945-5763
DOI:10.46292/sci20-00062