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Interrelationship of Neurogenic Obesity and Chronic Neuropathic Pain in Persons With Spinal Cord Injury
The prevalence of obesity and of neuropathic pain are both estimated at above 50% in the population of people with chronic spinal cord injury (SCI). These secondary consequences of SCI have significant negative impact on physical functioning, activities of daily living, and quality of life. Investig...
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| Published in: | Topics in spinal cord injury rehabilitation 2021, Vol.27 (1), p.75-83 |
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| cites | cdi_FETCH-LOGICAL-c412t-904936ee89064d3edfbe12f867df59d38d09c26562b777ee3144e5615b791d7a3 |
| container_end_page | 83 |
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| container_title | Topics in spinal cord injury rehabilitation |
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| creator | Felix, Elizabeth R Gater, Jr, David R |
| description | The prevalence of obesity and of neuropathic pain are both estimated at above 50% in the population of people with chronic spinal cord injury (SCI). These secondary consequences of SCI have significant negative impact on physical functioning, activities of daily living, and quality of life. Investigations of relationships between weight or body composition and chronic neuropathic pain in people with SCI are lacking, but investigations in non-SCI cohorts suggest an association between obesity and the presence and severity of neuropathic pain conditions. In the present article, we present a review of the literature linking obesity and neuropathic pain and summarize findings suggesting that metabolic syndrome and chronic, systemic inflammation due to excess adiposity increase the risk for neuropathic pain after an SCI. |
| doi_str_mv | 10.46292/sci20-00062 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1082-0744 |
| ispartof | Topics in spinal cord injury rehabilitation, 2021, Vol.27 (1), p.75-83 |
| issn | 1082-0744 1945-5763 1945-5763 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7983640 |
| source | Open Access: PubMed Central |
| subjects | Body fat Body mass index Chronic pain Cytokines Gastrointestinal surgery Humans Metabolic syndrome Metabolic Syndrome - etiology Nervous system Neuralgia - etiology Neuralgia - metabolism Obesity Obesity - complications Overweight Pain Risk Factors Spinal cord injuries Spinal Cord Injuries - complications Weight control |
| title | Interrelationship of Neurogenic Obesity and Chronic Neuropathic Pain in Persons With Spinal Cord Injury |
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