Association between psoriasis, psoriatic arthritis and gastrointestinal disease: An exploratory nationwide inpatient sample analysis

Summary Background Psoriasis is associated with cardiovascular disease, inflammatory bowel disease (IBD), metabolic syndrome, and psychiatric disease. Furthermore, psoriasis is associated with immune dysregulation and systemic inflammation. Objective To determine the association of psoriasis and pso...

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Bibliographic Details
Published in:Wiener Klinische Wochenschrift 2021-06, Vol.133 (11-12), p.586-593
Main Authors: Yousaf, Ahmed, Raiker, Rahul, Davis, Stephen M., Gayam, Swapna, Zinn, Zachary
Format: Article
Language:English
Subjects:
Endocrinology
Gastroenterology
Internal Medicine
Medicine
Medicine & Public Health
Original Article
Pneumology/Respiratory System
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Summary:Summary Background Psoriasis is associated with cardiovascular disease, inflammatory bowel disease (IBD), metabolic syndrome, and psychiatric disease. Furthermore, psoriasis is associated with immune dysregulation and systemic inflammation. Objective To determine the association of psoriasis and psoriatic arthritis with IBD and the association of the combination of psoriasis or psoriatic arthritis with IBD and other gastrointestinal illnesses. Methods Discharge data from the 2000–2014 Nationwide Inpatient Sample, Healthcare Cost and Utilization Project (HCUP), which approximates a 20% stratified sample of all US hospitalizations, were analyzed. Multivariable logistic regression was used to examine the association between psoriasis and psoriatic arthritis with IBD and 23 gastrointestinal illnesses adjusting for sociodemographic characteristics. Results Psoriasis was associated with IBD (Crohn’s disease adjusted odds ratio (aOR) = 2.13, 95% confidence interval (CI) [2.0–2.3], p  
ISSN:0043-5325
1613-7671
DOI:10.1007/s00508-020-01740-8