The bioinformatics toolbox for circRNA discovery and analysis

Abstract Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent advances in sequencing technologies and bioinformatics tools have led directly to an ever-expanding field of types a...

Full description

Saved in:
Bibliographic Details
Published in:Briefings in bioinformatics 2021-03, Vol.22 (2), p.1706-1728
Main Authors: Chen, Liang, Wang, Changliang, Sun, Huiyan, Wang, Juexin, Liang, Yanchun, Wang, Yan, Wong, Garry
Format: Article
Language:English
Subjects:
Annotations
Bioinformatics
Biomarkers
Gene sequencing
Network analysis
Review
Ribonucleic acid
RNA
Splicing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent advances in sequencing technologies and bioinformatics tools have led directly to an ever-expanding field of types and biological functions of circRNAs. In parallel with technological developments, practical applications of circRNAs have arisen including their utilization as biomarkers of human disease. Currently, circRNA-associated bioinformatics tools can support projects including circRNA annotation, circRNA identification and network analysis of competing endogenous RNA (ceRNA). In this review, we collected about 100 circRNA-associated bioinformatics tools and summarized their current attributes and capabilities. We also performed network analysis and text mining on circRNA tool publications in order to reveal trends in their ongoing development.
ISSN:1477-4054
1467-5463
1477-4054
DOI:10.1093/bib/bbaa001