The Association Between Inflammation and Immunosuppression: Implications for ICI Biomarker Development

Evasion of immune destruction is considered one of the hallmarks of cancer. Chronic inflammation can enable immune escape by suppressing immune surveillance and permitting the development of tumors and creating a tumor microenvironment that sustains cancer. This includes generating mechanisms that p...

Full description

Saved in:
Bibliographic Details
Published in:OncoTargets and therapy 2021-01, Vol.14, p.2053-2064
Main Authors: Sacdalan, Danielle Benedict, Lucero, Josephine Anne
Format: Article
Language:English
Subjects:
Antigens
Apoptosis
B cells
Biomarkers
Cancer
Cell cycle
Cell growth
Cytokines
Cytotoxicity
Dendritic cells
Development and progression
DNA methylation
Gene expression
Growth factors
Immune checkpoint inhibitors
Immune response
Immune system
Immunosuppression
Immunosurveillance
Immunotherapy
Inflammation
Kinases
Ligands
Lymphocytes
Neutrophils
Pathogens
Proteins
Review
Signal transduction
Tumor microenvironment
Tumor necrosis factor-TNF
Tumorigenesis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Evasion of immune destruction is considered one of the hallmarks of cancer. Chronic inflammation can enable immune escape by suppressing immune surveillance and permitting the development of tumors and creating a tumor microenvironment that sustains cancer. This includes generating mechanisms that prevent the effectiveness of anti-tumor treatment including immune checkpoint inhibitor therapy. In this review, we explore the interplay of inflammation and immunosuppression, their effects on the tumor microenvironment, and their implications for immune checkpoint inhibitor therapy particularly in the context of predictive biomarkers for their use.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S278089