A branched‐chain amino acid‐based metabolic score can predict liver fat in children and adolescents with severe obesity

Summary Background Eighty percent of adolescents with severe obesity suffer from non‐alcoholic fatty liver disease (NAFLD). Non‐invasive prediction models have been tested in adults, however, they performed poorly in paediatric populations. Objective This study aimed to investigate novel biomarkers...

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Bibliographic Details
Published in:Pediatric obesity 2021-04, Vol.16 (4), p.e12739-n/a
Main Authors: Lischka, Julia, Schanzer, Andrea, Hojreh, Azadeh, Ba Ssalamah, Ahmed, Item, Chike Bellarmine, Gier, Charlotte, Walleczek, Nina‐Katharina, Metz, Thomas F., Jakober, Ivana, Greber‐Platzer, Susanne, Zeyda, Maximilian
Format: Article
Language:English
Subjects:
Amino acids
biomarker
branched‐chain amino acids
Childrens health
metabolic score
Metabolism
non‐alcoholic fatty liver disease
Obesity
Original Research
pediatric obesity
Pediatrics
Teenagers
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Summary:Summary Background Eighty percent of adolescents with severe obesity suffer from non‐alcoholic fatty liver disease (NAFLD). Non‐invasive prediction models have been tested in adults, however, they performed poorly in paediatric populations. Objective This study aimed to investigate novel biomarkers for NAFLD and to develop a score that predicts liver fat in youth with severe obesity. Methods From a population with a BMI >97th percentile aged 9‐19 years (n = 68), clinically thoroughly characterized including MRI‐derived proton density fat fraction (MRI‐PDFF), amino acids and acylcarnitines were measured by HPLC‐MS. Results In children with NAFLD, higher levels of plasma branched‐chain amino acids (BCAA) were determined. BCAAs correlated with MRI‐PDFF (R = 0.46, p 
ISSN:2047-6302
2047-6310
DOI:10.1111/ijpo.12739