Influence of SARS-CoV-2 during pregnancy: a placental view

Since the beginning of the current coronavirus outbreak (COVID-19), there has been great concern over a disease that has spread rapidly in several countries worldwide, with the result of several deaths, including deaths of pregnant women. Therefore, the aim of this study was to conduct a literature...

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Bibliographic Details
Published in:Biology of Reproduction 2021-06, Vol.104 (6), p.1189-1193
Main Authors: Santos da Costa, Marcos Aurélio, Lapa de Albuquerque Britto, Diana Babini, da Silva, Maria Eduarda, de Carvalho, Jennyfer Martins, Figueira de Oliveira, Maria Luísa, da Silva Gomes, José Anderson, Chagas Angelo Mendes Tenorio, Fernanda das, Leite, Sônia Pereira
Format: Article
Language:English
Subjects:
Amniotic fluid
Coronaviruses
COVID-19
Disease transmission
Fetuses
Literature reviews
maternal–fetal
Morphology
Peripheral blood
Placenta
Pregnancy
Pregnant women
REVIEW
Severe acute respiratory syndrome coronavirus 2
Umbilical cord
Viral infections
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Summary:Since the beginning of the current coronavirus outbreak (COVID-19), there has been great concern over a disease that has spread rapidly in several countries worldwide, with the result of several deaths, including deaths of pregnant women. Therefore, the aim of this study was to conduct a literature review on placental changes in infected pregnant women and/or asymptomatic carriers of COVID-19 during pregnancy, aiming at the possible vertical transmission. A systematic collection was carried out on the effects of that COVID-19 can cause directly and/or indirectly to pregnancy and the placenta in the following databases: Pubmed, Science Direct, Scielo, Lilacs, and Web of Science. For search, the following descriptors were used: placenta, pregnant woman, COVID-19, maternal–fetal. The results indicate transplacental transmission in some cases reviewed in many reports from this study. The presence of the virus was seen in the amniotic fluid, umbilical cord, and peripheral blood. Finally, pathological studies suggest that there are morphological changes related to infection in the placentas. We can conclude that, based on the researched material, there is little evidence of transplacental vertical viral transmission and its respective morphological changes related to viral infection in the placenta. Summary sentence There is small evidence of transplacental vertical viral transmission and its respective morphological changes related to viral infection in the placenta.
ISSN:0006-3363
1529-7268
DOI:10.1093/biolre/ioab037