The Promotional Effect of Hollow MnO2 with Brucea Javanica Oil Emulsion (BJOE) on Endometrial Cancer Apoptosis

Endometrial cancer (EC) is a common gynecological malignancy worldwide whose therapy mainly depends on chemotherapy. In past years, an increasing number of studies indicate that hollow MnO2 could serve as a nanoplatform in the drug delivery system. The Brucea javanica oil emulsion (BJOE) has been il...

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Bibliographic Details
Published in:BioMed research international 2021-03, Vol.2021, p.1-7
Main Authors: Hu, Qin, Zhang, Shu, Zhu, Jun, Yin, Lina, Liu, Suping, Huang, Xiaowei, Ke, Guihao
Format: Article
Language:English
Subjects:
Apoptosis
Cancer
Cancer therapies
Cell growth
Cell proliferation
Chemical synthesis
Chemotherapy
Drug delivery
Drug delivery systems
Endometrial cancer
Endometrium
Estrogens
Ethanol
Malignancy
Manganese dioxide
Morphology
Nanomaterials
Nanoparticles
Polyethylene glycol
Scanning electron microscopy
Tumor microenvironment
Variance analysis
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Summary:Endometrial cancer (EC) is a common gynecological malignancy worldwide whose therapy mainly depends on chemotherapy. In past years, an increasing number of studies indicate that hollow MnO2 could serve as a nanoplatform in the drug delivery system. The Brucea javanica oil emulsion (BJOE) has been illustrated to play a vital role in cancers. However, knowledge about the combined effect of H-MnO2-PEG/BJOE in endometrial cancer remains ambiguous up to now. In the present work, we prepared a drug-delivery vector H-MnO2-PEG by chemical synthesis and found that H-MnO2-PEG significantly inhibited cell proliferation in endometrial cancer cells. Moreover, the combination of H-MnO2-PEG/BJOE could repress cell proliferation more efficiently and promote cell apoptosis. Mechanistically, we found that BJOE exerted its role as a promoter of endometrial apoptosis by regulating relative protein expressions. In general, the present study demonstrates that H-MnO2-PEG functions as a critical vector in the tumor microenvironment of endometrial cancer and the significant effect of H-MnO2-PEG/BJOE on cancer cells, suggesting a new paradigm for the treatment of endometrial cancer.
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/6631533