Liver Metastasectomy for Metastatic Breast Cancer Patients: A Single Institution Retrospective Analysis

The liver represents the first metastatic site in 5-12% of metastatic breast cancer (MBC) cases. In absence of reliable evidence, liver metastasectomy (LM) could represent a possible therapeutic option for selected MBC patients (patients) in clinical practice. A retrospective analysis including MBC...

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Bibliographic Details
Published in:Journal of personalized medicine 2021-03, Vol.11 (3), p.187
Main Authors: Orlandi, Armando, Pontolillo, Letizia, Mele, Caterina, Pasqualoni, Mariangela, Pannunzio, Sergio, Cannizzaro, Maria Chiara, Cutigni, Claudia, Palazzo, Antonella, Garufi, Giovanna, Vellone, Maria, Ardito, Francesco, Franceschini, Gianluca, Sanchez, Alejandro Martin, Cassano, Alessandra, Giuliante, Felice, Bria, Emilio, Tortora, Giampaolo
Format: Article
Language:English
Subjects:
Abscesses
Age
Breast cancer
Cancer therapies
Liver
Metastases
Metastasis
Mortality
Patients
Precision medicine
Software
Surgery
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Summary:The liver represents the first metastatic site in 5-12% of metastatic breast cancer (MBC) cases. In absence of reliable evidence, liver metastasectomy (LM) could represent a possible therapeutic option for selected MBC patients (patients) in clinical practice. A retrospective analysis including MBC patients who had undergone an LM after a multidisciplinary Tumor Board discussion at the Hepatobiliary Surgery Unit of Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS in Rome, between January 1994 and December 2019 was conducted. The primary endpoint was overall survival (OS) after a MBC-LM; the secondary endpoint was the disease-free interval (DFI) after surgery. Forty-nine MBC patients underwent LM, but clinical data were only available for 22 patients. After a median follow-up of 71 months, median OS and DFI were 67 months (95% CI 45-103) and 15 months (95% CI 11-46), respectively. At univariate analysis, the presence of a negative resection margin (R0) was the only factor that statistically significantly influenced OS (78 months 16 months; HR 0.083, < 0.0001) and DFI (16 months 5 months; HR 0.17, = 0.0058). A LM for MBC might represent a therapeutic option for selected patients. The radical nature of the surgical procedure performed in a high-flow center and after a multidisciplinary discussion appears essential for this therapeutic option.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11030187