Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development-Review

• Published in: International journal of molecular sciences 2021-03, Vol.22 (6), p.2935
• Main Authors: Łukasik, Paweł, Załuski, Michał, Gutowska, Izabela
• Format: Article
• Language: English
• Subjects: Alzheimer Disease - drug therapy; Alzheimer Disease - enzymology; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Animals; Antineoplastic Agents - therapeutic use; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Cardiomegaly - drug therapy; Cardiomegaly - enzymology; Cardiomegaly - genetics; Cardiomegaly - pathology; Cardiovascular Agents - therapeutic use; Cell cycle; Cell Cycle - drug effects; Cell Cycle - genetics; Cell division; Cyclin-dependent kinases; Cyclin-Dependent Kinases - antagonists & inhibitors; Cyclin-Dependent Kinases - genetics; Cyclin-Dependent Kinases - metabolism; Cyclins - genetics; Cyclins - metabolism; Deoxyribonucleic acid; Deregulation; DNA; Enzymes; Fibroblasts; Gene expression; Gene Expression Regulation; Humans; Kinases; Neoplasms - drug therapy; Neoplasms - enzymology; Neoplasms - genetics; Neoplasms - pathology; Nervous system; Neurogenesis; Neuroprotective Agents - therapeutic use; Parkinson Disease - drug therapy; Parkinson Disease - enzymology; Parkinson Disease - genetics; Parkinson Disease - pathology; Parkinson's disease; Phosphorylation; Protein Kinase Inhibitors - therapeutic use; Proteins; Review; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Stroke - drug therapy; Stroke - enzymology; Stroke - genetics; Stroke - pathology; Transcription; Transcription factors
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22062935

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle and transcription, as well as communication, metabolism, and apoptosis. The kinases are organized in a pathway to ensure that, during cell division, each cell accurately replicates its DNA, and ensure its segregation equally between the two daughter cells. Deregulation of any of the stages of the cell cycle or transcription leads to apoptosis but, if uncorrected, can result in a series of diseases, such as cancer, neurodegenerative diseases (Alzheimer's or Parkinson's disease), and stroke. This review presents the current state of knowledge about the characteristics of cyclin-dependent kinases as potential pharmacological targets.