Genetic Polymorphisms of 5-HT Receptors and Antipsychotic-Induced Metabolic Dysfunction in Patients with Schizophrenia

Antipsychotic-induced metabolic syndrome (MetS) is a multifactorial disease with a genetic predisposition. Serotonin and its receptors are involved in antipsychotic-drug-induced metabolic disorders. The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine...

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Bibliographic Details
Published in:Journal of personalized medicine 2021-03, Vol.11 (3), p.181
Main Authors: Paderina, Diana Z, Boiko, Anastasiia S, Pozhidaev, Ivan V, Bocharova, Anna V, Mednova, Irina A, Fedorenko, Olga Yu, Kornetova, Elena G, Loonen, Anton J M, Semke, Arkadiy V, Bokhan, Nikolay A, Ivanova, Svetlana A
Format: Article
Language:English
Subjects:
Antipsychotics
Body mass index
Communication
Diabetes
Dopamine
Drugs
Gene polymorphism
Genes
Genomics
Genotyping
Hospitals
Mental disorders
Mental health
Metabolic syndrome
Obesity
Patients
Precision medicine
Proteins
Psychotropic drugs
Schizophrenia
Serotonin transporter
Single-nucleotide polymorphism
Statistical analysis
Womens health
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Summary:Antipsychotic-induced metabolic syndrome (MetS) is a multifactorial disease with a genetic predisposition. Serotonin and its receptors are involved in antipsychotic-drug-induced metabolic disorders. The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine receptor ( ) genes , , , and and the gene encoding for the serotonin transporter with MetS in patients with schizophrenia. A set of nine single-nucleotide polymorphisms of genes of the serotonergic system was investigated in a population of 475 patients from several Siberian regions (Russia) with a clinical diagnosis of schizophrenia. Genotyping was performed and the results were analyzed using chi-square tests. Polymorphic variant rs521018 ( ) was associated with higher body mass index in patients receiving long-term antipsychotic therapy, but not with drug-induced metabolic syndrome. Rs1150226 ( ) was also associated but did not meet Hardy-Weinberg equilibrium. Our results indicate that allelic variants of genes may have consequences on metabolic parameters. MetS may have too complex a mechanistic background to be studied without dissecting the syndrome into its individual (causal) components.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11030181