Peripheral Blood MicroRNAs as Potential Biomarkers of Myocardial Damage in Acute Viral Myocarditis

microRNAs (miRs) have emerged as important modulators of cardiovascular development and disease. Our aim was to determine whether cardiac-related miRs such as miR-21-5p and miR-1-3p were differentially expressed in acute viral myocarditis and whether any of them was related with the extent of myocar...

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Bibliographic Details
Published in:Genes 2021-03, Vol.12 (3), p.420
Main Authors: Marketou, Maria, Kontaraki, Joanna, Patrianakos, Alexandros, Kochiadakis, George, Anastasiou, Ioannis, Fragkiadakis, Konstantinos, Plevritaki, Anthoula, Papadaki, Sofia Thalia, Chlouverakis, Gregory, Parthenakis, Fragiskos
Format: Article
Language:English
Subjects:
Age
Biomarkers
Calcium-binding protein
Cardiac arrhythmia
Cardiomyopathy
Cardiovascular disease
Coronary vessels
Ejection fraction
Electrocardiography
Heart diseases
Hospitals
Infections
Laboratories
Leukocytes (mononuclear)
Medical imaging
MicroRNAs
miRNA
Mortality
Myocarditis
Pain
Pathophysiology
Peripheral blood mononuclear cells
Polymerase chain reaction
Reverse transcription
Troponin
Troponin I
Ventricle
Viral infections
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Summary:microRNAs (miRs) have emerged as important modulators of cardiovascular development and disease. Our aim was to determine whether cardiac-related miRs such as miR-21-5p and miR-1-3p were differentially expressed in acute viral myocarditis and whether any of them was related with the extent of myocardial damage and left ventricular dysfunction. We enrolled 40 patients with acute viral myocarditis. Blood samples were taken on admission and miRs expression levels in peripheral blood mononuclear cells were quantified by real-time reverse transcription polymerase chain reaction. miR-21-5p, miR-1-3p were significantly elevated in acute myocarditis. miR-21-5p levels showed a strong correlation with global longitudinal strain ( = 0.71, < 0.01), while miR-1-3p had significant correlations with troponin I ( = 0.79, < 0.01). The expression of miR-21-5p and miR-1-3p in peripheral blood is increased in acute viral myocarditis, and this increase is correlated with myocardial damage and indicative of left ventricular systolic dysfunction in these patients.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes12030420