Lesson of the month: Severe leukoencephalopathy by SARS-CoV-2

Neurological manifestations associated with SARS-CoV-2 infection as well as its pathogenesis are insufficiently explained. We present two cases of severe COVID-19 who required hospitalisation in the intensive care unit with persistently depressed mental status and severe leukoencephalopathy. We disc...

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Bibliographic Details
Published in:Clinical medicine (London, England) England), 2021-03, Vol.21 (2), p.155-157
Main Authors: Sanz-Canalejas, Leticia, Polidura-Arruga, María del Carmen, Yus-Fuertes, Miguel, Jorquera-Moya, Manuela, Vidart-Simón, Nieves, Arrazola-García, Juan, Gómez-Ruiz, Natividad
Format: Article
Language:English
Subjects:
Anesthesia
brain
coronavirus
Coronaviruses
COVID-19
Diagnostic tests
Encephalitis
Infections
Intensive care
Ischemia
Lessons of the Month
leukoencephalopathy
Magnetic resonance imaging
MRI
Nervous system
Pathogenesis
Patients
Pneumonia
Severe acute respiratory syndrome coronavirus 2
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Summary:Neurological manifestations associated with SARS-CoV-2 infection as well as its pathogenesis are insufficiently explained. We present two cases of severe COVID-19 who required hospitalisation in the intensive care unit with persistently depressed mental status and severe leukoencephalopathy. We discuss the clinical and radiological findings and also propose the possible pathogenesis involved.
ISSN:1470-2118
1473-4893
DOI:10.7861/clinmed.2020-0940