Immunotherapy for ALK -Rearranged Non-Small Cell Lung Cancer: Challenges Inform Promising Approaches

Rearrangements in the Anaplastic Lymphoma Kinase ( ) gene have been implicated in 5-6% of all non-small cell lung cancers. -rearranged non-small cell lung cancers are sensitive to -directed tyrosine kinase inhibitors, but generally resistant to single-agent immune checkpoint inhibitors. Here, we aim...

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Bibliographic Details
Published in:Cancers 2021-03, Vol.13 (6), p.1476
Main Authors: Sankar, Kamya, Nagrath, Sunitha, Ramnath, Nithya
Format: Article
Language:English
Subjects:
Review
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Summary:Rearrangements in the Anaplastic Lymphoma Kinase ( ) gene have been implicated in 5-6% of all non-small cell lung cancers. -rearranged non-small cell lung cancers are sensitive to -directed tyrosine kinase inhibitors, but generally resistant to single-agent immune checkpoint inhibitors. Here, we aim to describe the mechanisms of aberrations in non-small cell lung cancer by which an immunosuppressed tumor microenvironment is created, leading to host immune evasion. We report pre-clinical and clinical studies evaluating novel immunotherapeutic approaches and describe the promises and challenges of incorporating immune-based treatments for -rearranged non-small cell lung cancer.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13061476