Immunotherapy for ALK -Rearranged Non-Small Cell Lung Cancer: Challenges Inform Promising Approaches

Rearrangements in the Anaplastic Lymphoma Kinase ( ) gene have been implicated in 5-6% of all non-small cell lung cancers. -rearranged non-small cell lung cancers are sensitive to -directed tyrosine kinase inhibitors, but generally resistant to single-agent immune checkpoint inhibitors. Here, we aim...

Full description

Saved in:
Bibliographic Details
Published in:Cancers 2021-03, Vol.13 (6), p.1476
Main Authors: Sankar, Kamya, Nagrath, Sunitha, Ramnath, Nithya
Format: Article
Language:English
Subjects:
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c393t-2d0bb9d87fa3ed24bfbae039ab0ef87f9875cb6149ea8165d2dd574f685dd6883
cites cdi_FETCH-LOGICAL-c393t-2d0bb9d87fa3ed24bfbae039ab0ef87f9875cb6149ea8165d2dd574f685dd6883
container_end_page
container_issue 6
container_start_page 1476
container_title Cancers
container_volume 13
creator Sankar, Kamya
Nagrath, Sunitha
Ramnath, Nithya
description Rearrangements in the Anaplastic Lymphoma Kinase ( ) gene have been implicated in 5-6% of all non-small cell lung cancers. -rearranged non-small cell lung cancers are sensitive to -directed tyrosine kinase inhibitors, but generally resistant to single-agent immune checkpoint inhibitors. Here, we aim to describe the mechanisms of aberrations in non-small cell lung cancer by which an immunosuppressed tumor microenvironment is created, leading to host immune evasion. We report pre-clinical and clinical studies evaluating novel immunotherapeutic approaches and describe the promises and challenges of incorporating immune-based treatments for -rearranged non-small cell lung cancer.
doi_str_mv 10.3390/cancers13061476
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8004790</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2508573603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-2d0bb9d87fa3ed24bfbae039ab0ef87f9875cb6149ea8165d2dd574f685dd6883</originalsourceid><addsrcrecordid>eNpdUctOwzAQtBAIUOmZG_KRS8CJEz84IFURj4oKEI-z5cSbNqixg90g9e8xFBDgg73anZ317CB0mJITSiU5rbWtwYeUEpbmnG2h_YzwLGFM5tu_4j00DuGFxENpyhnfRXuUCsIk5_vITLtusG61AK_7NW6cx5PZDU4eQHuv7RwMvnU2eez0colLiNdssHNcfo4-w-Ui5iHCAp7a2Nzhe--6NrQRM-l773S9gHCAdhq9DDD-ekfo-fLiqbxOZndX03IyS2oq6SrJDKkqaQRvNAWT5VVTaSBU6opAE7NS8KKuolYJWqSsMJkxBc8bJgpjmBB0hM43vP1QdWBqsCuvl6r3baf9Wjndqr8V2y7U3L0pQUjOJYkEx18E3r0OEFYqaqmjam3BDUFlBREFpyxucoRON9DauxA8ND9jUqI-7FH_7IkdR79_94P_NoO-A2X9jpA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2508573603</pqid></control><display><type>article</type><title>Immunotherapy for ALK -Rearranged Non-Small Cell Lung Cancer: Challenges Inform Promising Approaches</title><source>Access via ProQuest (Open Access)</source><source>PubMed Central Free</source><creator>Sankar, Kamya ; Nagrath, Sunitha ; Ramnath, Nithya</creator><creatorcontrib>Sankar, Kamya ; Nagrath, Sunitha ; Ramnath, Nithya</creatorcontrib><description>Rearrangements in the Anaplastic Lymphoma Kinase ( ) gene have been implicated in 5-6% of all non-small cell lung cancers. -rearranged non-small cell lung cancers are sensitive to -directed tyrosine kinase inhibitors, but generally resistant to single-agent immune checkpoint inhibitors. Here, we aim to describe the mechanisms of aberrations in non-small cell lung cancer by which an immunosuppressed tumor microenvironment is created, leading to host immune evasion. We report pre-clinical and clinical studies evaluating novel immunotherapeutic approaches and describe the promises and challenges of incorporating immune-based treatments for -rearranged non-small cell lung cancer.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers13061476</identifier><identifier>PMID: 33806977</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Review</subject><ispartof>Cancers, 2021-03, Vol.13 (6), p.1476</ispartof><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-2d0bb9d87fa3ed24bfbae039ab0ef87f9875cb6149ea8165d2dd574f685dd6883</citedby><cites>FETCH-LOGICAL-c393t-2d0bb9d87fa3ed24bfbae039ab0ef87f9875cb6149ea8165d2dd574f685dd6883</cites><orcidid>0000-0002-1497-7977</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004790/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004790/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33806977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sankar, Kamya</creatorcontrib><creatorcontrib>Nagrath, Sunitha</creatorcontrib><creatorcontrib>Ramnath, Nithya</creatorcontrib><title>Immunotherapy for ALK -Rearranged Non-Small Cell Lung Cancer: Challenges Inform Promising Approaches</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Rearrangements in the Anaplastic Lymphoma Kinase ( ) gene have been implicated in 5-6% of all non-small cell lung cancers. -rearranged non-small cell lung cancers are sensitive to -directed tyrosine kinase inhibitors, but generally resistant to single-agent immune checkpoint inhibitors. Here, we aim to describe the mechanisms of aberrations in non-small cell lung cancer by which an immunosuppressed tumor microenvironment is created, leading to host immune evasion. We report pre-clinical and clinical studies evaluating novel immunotherapeutic approaches and describe the promises and challenges of incorporating immune-based treatments for -rearranged non-small cell lung cancer.</description><subject>Review</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdUctOwzAQtBAIUOmZG_KRS8CJEz84IFURj4oKEI-z5cSbNqixg90g9e8xFBDgg73anZ317CB0mJITSiU5rbWtwYeUEpbmnG2h_YzwLGFM5tu_4j00DuGFxENpyhnfRXuUCsIk5_vITLtusG61AK_7NW6cx5PZDU4eQHuv7RwMvnU2eez0colLiNdssHNcfo4-w-Ui5iHCAp7a2Nzhe--6NrQRM-l773S9gHCAdhq9DDD-ekfo-fLiqbxOZndX03IyS2oq6SrJDKkqaQRvNAWT5VVTaSBU6opAE7NS8KKuolYJWqSsMJkxBc8bJgpjmBB0hM43vP1QdWBqsCuvl6r3baf9Wjndqr8V2y7U3L0pQUjOJYkEx18E3r0OEFYqaqmjam3BDUFlBREFpyxucoRON9DauxA8ND9jUqI-7FH_7IkdR79_94P_NoO-A2X9jpA</recordid><startdate>20210323</startdate><enddate>20210323</enddate><creator>Sankar, Kamya</creator><creator>Nagrath, Sunitha</creator><creator>Ramnath, Nithya</creator><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1497-7977</orcidid></search><sort><creationdate>20210323</creationdate><title>Immunotherapy for ALK -Rearranged Non-Small Cell Lung Cancer: Challenges Inform Promising Approaches</title><author>Sankar, Kamya ; Nagrath, Sunitha ; Ramnath, Nithya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-2d0bb9d87fa3ed24bfbae039ab0ef87f9875cb6149ea8165d2dd574f685dd6883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sankar, Kamya</creatorcontrib><creatorcontrib>Nagrath, Sunitha</creatorcontrib><creatorcontrib>Ramnath, Nithya</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sankar, Kamya</au><au>Nagrath, Sunitha</au><au>Ramnath, Nithya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunotherapy for ALK -Rearranged Non-Small Cell Lung Cancer: Challenges Inform Promising Approaches</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2021-03-23</date><risdate>2021</risdate><volume>13</volume><issue>6</issue><spage>1476</spage><pages>1476-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Rearrangements in the Anaplastic Lymphoma Kinase ( ) gene have been implicated in 5-6% of all non-small cell lung cancers. -rearranged non-small cell lung cancers are sensitive to -directed tyrosine kinase inhibitors, but generally resistant to single-agent immune checkpoint inhibitors. Here, we aim to describe the mechanisms of aberrations in non-small cell lung cancer by which an immunosuppressed tumor microenvironment is created, leading to host immune evasion. We report pre-clinical and clinical studies evaluating novel immunotherapeutic approaches and describe the promises and challenges of incorporating immune-based treatments for -rearranged non-small cell lung cancer.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>33806977</pmid><doi>10.3390/cancers13061476</doi><orcidid>https://orcid.org/0000-0002-1497-7977</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2072-6694
ispartof Cancers, 2021-03, Vol.13 (6), p.1476
issn 2072-6694
2072-6694
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8004790
source Access via ProQuest (Open Access); PubMed Central Free
subjects Review
title Immunotherapy for ALK -Rearranged Non-Small Cell Lung Cancer: Challenges Inform Promising Approaches
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A26%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunotherapy%20for%20ALK%20-Rearranged%20Non-Small%20Cell%20Lung%20Cancer:%20Challenges%20Inform%20Promising%20Approaches&rft.jtitle=Cancers&rft.au=Sankar,%20Kamya&rft.date=2021-03-23&rft.volume=13&rft.issue=6&rft.spage=1476&rft.pages=1476-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers13061476&rft_dat=%3Cproquest_pubme%3E2508573603%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c393t-2d0bb9d87fa3ed24bfbae039ab0ef87f9875cb6149ea8165d2dd574f685dd6883%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2508573603&rft_id=info:pmid/33806977&rfr_iscdi=true