Research progress on coronavirus S proteins and their receptors

Coronaviruses are a large family of important pathogens that cause human and animal diseases. At the end of 2019, a pneumonia epidemic caused by a novel coronavirus brought attention to coronaviruses. Exploring the interaction between the virus and its receptor will be helpful in developing preventi...

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Bibliographic Details
Published in:Archives of virology 2021-07, Vol.166 (7), p.1811-1817
Main Authors: Yuan, Hao-Wen, Wen, Hong-Ling
Format: Article
Language:English
Subjects:
Animal diseases
Binding Sites
Biomedical and Life Sciences
Biomedicine
Cell fusion
Cell membranes
Coronavirus - chemistry
Coronavirus - metabolism
Coronavirus - physiology
Coronaviruses
COVID-19 - metabolism
COVID-19 - virology
Humans
Infectious Diseases
Medical Microbiology
Membrane fusion
Protein Binding
Protein Conformation
Receptors, Virus - classification
Receptors, Virus - metabolism
Review
SARS-CoV-2 - chemistry
SARS-CoV-2 - metabolism
SARS-CoV-2 - physiology
Spike Glycoprotein, Coronavirus - chemistry
Spike Glycoprotein, Coronavirus - classification
Spike Glycoprotein, Coronavirus - metabolism
Spike protein
Structure-function relationships
Virology
Virus Internalization
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Summary:Coronaviruses are a large family of important pathogens that cause human and animal diseases. At the end of 2019, a pneumonia epidemic caused by a novel coronavirus brought attention to coronaviruses. Exploring the interaction between the virus and its receptor will be helpful in developing preventive vaccines and therapeutic drugs. The coronavirus spike protein (S) plays an important role in both binding to receptors on host cells and fusion of the viral membrane with the host cell membrane. This review introduces the structure and function of the S protein and its receptor, focusing on the binding mode and binding region of both.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-021-05008-y