Role of B Cells in Multiple Sclerosis and Related Disorders

The success of clinical trials of selective B‐cell depletion in patients with relapsing multiple sclerosis (MS) and primary progressive MS has led to a conceptual shift in the understanding of MS pathogenesis, away from the classical model in which T cells were the sole central actors and toward a m...

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Bibliographic Details
Published in:Annals of neurology 2021-01, Vol.89 (1), p.13-23
Main Authors: Comi, Giancarlo, Bar‐Or, Amit, Lassmann, Hans, Uccelli, Antonio, Hartung, Hans‐Peter, Montalban, Xavier, Sørensen, Per Solberg, Hohlfeld, Reinhard, Hauser, Stephen L.
Format: Article
Language:English
Subjects:
Autoantibodies - immunology
B-Lymphocytes - cytology
Central Nervous System - immunology
Clinical trials
Depletion
Humans
Inflammation
Lymphocytes
Lymphocytes B
Lymphocytes T
Multiple sclerosis
Multiple Sclerosis - immunology
Multiple Sclerosis - pathology
Pathogenesis
T-Lymphocytes - cytology
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Summary:The success of clinical trials of selective B‐cell depletion in patients with relapsing multiple sclerosis (MS) and primary progressive MS has led to a conceptual shift in the understanding of MS pathogenesis, away from the classical model in which T cells were the sole central actors and toward a more complex paradigm with B cells having an essential role in both the inflammatory and neurodegenerative components of the disease process. The role of B cells in MS was selected as the topic of the 27th Annual Meeting of the European Charcot Foundation. Results of the meeting are presented in this concise review, which recaps current concepts underlying the biology and therapeutic rationale behind B‐cell–directed therapeutics in MS, and proposes strategies to optimize the use of existing anti–B‐cell treatments and provide future directions for research in this area. ANN NEUROL 2021;89:13–23
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.25927