Sex‐based differences in severity and mortality in COVID‐19

Summary The current coronavirus disease (COVID‐19) pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has a male bias in severity and mortality. This is consistent with previous coronavirus pandemics such as SARS‐CoV and MERS‐CoV, and viral infections in general. H...

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Bibliographic Details
Published in:Reviews in medical virology 2021-11, Vol.31 (6), p.e2223-n/a
Main Authors: Alwani, Mustafa, Yassin, Aksam, Al‐Zoubi, Raed M., Aboumarzouk, Omar M., Nettleship, Joanne, Kelly, Daniel, AL‐Qudimat, Ahmad R., Shabsigh, Ridwan
Format: Article
Language:English
Subjects:
Coronaviruses
COVID-19
dimorphism
Epidemiology
Mortality
Pandemics
Review
Severe acute respiratory syndrome coronavirus 2
sex
Sexual dimorphism
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Summary:Summary The current coronavirus disease (COVID‐19) pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has a male bias in severity and mortality. This is consistent with previous coronavirus pandemics such as SARS‐CoV and MERS‐CoV, and viral infections in general. Here, we discuss the sex‐disaggregated epidemiological data for COVID‐19 and highlight underlying differences that may explain the sexual dimorphism to help inform risk stratification strategies and therapeutic options.
ISSN:1052-9276
1099-1654
DOI:10.1002/rmv.2223