Association of Monocyte Chemotactic Protein-1 and Dickkopf-1 with Body Composition and Physical Performance in Community-Dwelling Older Adults in Singapore

We aim to determine the association of monocyte chemotactic protein-1 (MCP-1) and dickkopft-1 (DKK-1) as potential biomarkers that may predict changes in body composition and physical performance in healthy older adults from Singapore. Two-hundred community-dwelling older adults (mean age: 67.9 year...

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Published in:Journal of frailty, sarcopenia and falls sarcopenia and falls, 2021-03, Vol.6 (1), p.25-31
Main Authors: Afandy, Nathania Octaviani, Lock, Hui Shan, Tay, Laura, Yeo, Audrey, Yew, Suzanne, Leung, Bernard P, Lim, Wee Shiong
Format: Article
Language:English
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Summary:We aim to determine the association of monocyte chemotactic protein-1 (MCP-1) and dickkopft-1 (DKK-1) as potential biomarkers that may predict changes in body composition and physical performance in healthy older adults from Singapore. Two-hundred community-dwelling older adults (mean age: 67.9 years; 68.5% females) were classified into elevated versus non-elevated groups based on quintile cut-offs of MCP-1 and DKK-1 levels (156.02 pg/mL and 606.31 pg/mL, respectively). Multiple linear regression was performed to examine the relationship between MCP-1 and DKK-1 with body composition and physical performance, adjusted for age, gender and ethnicity. MCP-1 was significantly associated with higher fat mass, fat mass index, percentage body fat, waist circumference and trunk-limb ratio for fat mass (all p
ISSN:2459-4148
2459-4148
DOI:10.22540/JFSF-06-025