Organoids: An invaluable tool in pharmacology

• Published in: Indian journal of pharmacology 2020-09, Vol.52 (5), p.422-429
• Main Authors: Balakrishnan, Sadasivam, Atal, Shubham, Ray, Avik, Pravin, C, Nanda, Malaya
• Format: Article
• Language: English
• Subjects: Bioengineering; Cell culture; Educational Forum; Health aspects; Pharmacology; Stem cells
• ISSN: 0253-7613; 1998-3751
• DOI: 10.4103/ijp.IJP_137_19

Advances in stem cell cultures and human-induced pluripotent stem cells have inculcated interests in a rapidly evolving concept - "organoids." These are three-dimensional (3D) structures mimicking some of the phenomena of the real organs at anatomical, multicellular, and functional levels in vitro. Organoids have been proven to be better than two-dimensional cell culture in replicating the functionality, architectural, and geometrical features of tissues in vivo. Recent advancements have led to the generation of models for organ development and disease, finding applications in the drug discovery, screening of novel compounds, and personalized medicine. Since organoids follow the same natural pathway as the normal tissue or pathology, they can be used to study the expression of various genotypes and phenotypic variations across different species. In the light of these advancements, organoids are now being merged with bioengineering to come up with even better and reliable models to predict the disease progression and effectiveness of precision medicines, few of its important applications. This article discusses the various aspects of this emerging concept along with its uses, both in the present times and near future, with a special focus on pharmacological applications.