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Impact of prescription drug monitoring program mandate on postoperative opioid prescriptions in children
Purpose Prescription drug monitoring programs (PDMPs) have been established to combat the opioid epidemic, but there is no data on their efficacy in children. We hypothesized that a statewide PDMP mandate would be associated with fewer opioid prescriptions in pediatric surgical patients. Methods Pat...
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| Published in: | Pediatric surgery international 2021-05, Vol.37 (5), p.659-665 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c474t-f1dd8566afd6bf3447bf74602ef1914b549e06b9d8e12dac5ddeeb4fe003a323 |
| container_end_page | 665 |
| container_issue | 5 |
| container_start_page | 659 |
| container_title | Pediatric surgery international |
| container_volume | 37 |
| creator | Theodorou, Christina M. Jackson, Jordan E. Rajasekar, Ganesh Nuño, Miriam Yamashiro, Kaeli J. Farmer, Diana L. Hirose, Shinjiro Brown, Erin G. |
| description | Purpose
Prescription drug monitoring programs (PDMPs) have been established to combat the opioid epidemic, but there is no data on their efficacy in children. We hypothesized that a statewide PDMP mandate would be associated with fewer opioid prescriptions in pediatric surgical patients.
Methods
Patients |
| doi_str_mv | 10.1007/s00383-020-04846-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8026407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2509430635</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-f1dd8566afd6bf3447bf74602ef1914b549e06b9d8e12dac5ddeeb4fe003a323</originalsourceid><addsrcrecordid>eNp9kU1vFSEUhonR2Gv1D7gwk7hxM3r4GBg2Jqbxo0kTN90TZoB7aWYAgWnivy_XW6t14YqE8_DCy4PQawzvMYD4UADoSHsg0AMbGe_JE7TDjIpejpg-RTvAQvZAh_EMvSjlBgBGyuVzdEYpo5RzukOHyzXpuXbRdSnbMmefqo-hM3nbd2sMvsbsw74N4z7rtVt1MLrariEplhqTzbr627aRfPTmUUjpfOjmg19MtuEleub0Uuyr-_UcXX_5fH3xrb_6_vXy4tNVPzPBau-wMePAuXaGT44yJiYnGAdiHZaYTQOTFvgkzWgxMXoejLF2Ys62v9CU0HP08RSbtmm1ZrahZr2olP2q808VtVePJ8Ef1D7eqhEIZyBawLv7gBx_bLZUtfoy22XRwcatKMKEIBxLKhv69h_0Jm45tHaKDCAZBU6HRpETNedYSrbu4TEY1NGjOnlUzaP65VEda7z5u8bDkd_iGkBPQElHPzb_ufs_sXdjWqxk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2509430635</pqid></control><display><type>article</type><title>Impact of prescription drug monitoring program mandate on postoperative opioid prescriptions in children</title><source>Springer Nature</source><creator>Theodorou, Christina M. ; Jackson, Jordan E. ; Rajasekar, Ganesh ; Nuño, Miriam ; Yamashiro, Kaeli J. ; Farmer, Diana L. ; Hirose, Shinjiro ; Brown, Erin G.</creator><creatorcontrib>Theodorou, Christina M. ; Jackson, Jordan E. ; Rajasekar, Ganesh ; Nuño, Miriam ; Yamashiro, Kaeli J. ; Farmer, Diana L. ; Hirose, Shinjiro ; Brown, Erin G.</creatorcontrib><description>Purpose
Prescription drug monitoring programs (PDMPs) have been established to combat the opioid epidemic, but there is no data on their efficacy in children. We hypothesized that a statewide PDMP mandate would be associated with fewer opioid prescriptions in pediatric surgical patients.
Methods
Patients < 18 undergoing inguinal hernia repair, orchiopexy, orchiectomy, appendectomy, or cholecystectomy at a tertiary children’s hospital were included. The primary outcome, discharge opioid prescription, was compared for 10 months pre-PDMP (
n
= 158) to 10 months post-PDMP (
n
= 228). Interrupted time series analysis was performed to determine the effect of the PDMP on opioid prescribing.
Results
Over the 20-month study period, there was an overall decrease in the rate of opioid prescriptions per month (− 3.6% change,
p
< 0.001). On interrupted time series analysis, PDMP implementation was not associated with a significant decrease in the monthly rate of opioid prescriptions (1.27% change post-PDMP,
p
= 0.4). However, PDMP implementation was associated with a reduction in opioid prescriptions of greater than 5 days’ supply (− 2.7% per month,
p
= 0.03).
Conclusion
Opioid prescriptions declined in pediatric surgical patients over the study time period. State-wide PDMP implementation was associated with a reduction in postoperative opioid prescriptions of more than 5 days’ duration.</description><identifier>ISSN: 0179-0358</identifier><identifier>EISSN: 1437-9813</identifier><identifier>DOI: 10.1007/s00383-020-04846-2</identifier><identifier>PMID: 33433663</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Medicine ; Medicine & Public Health ; Narcotics ; Original ; Original Article ; Pediatric Surgery ; Pediatrics ; Postoperative period ; Prescriptions ; Surgery ; Therapeutic drug monitoring ; Time series</subject><ispartof>Pediatric surgery international, 2021-05, Vol.37 (5), p.659-665</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-f1dd8566afd6bf3447bf74602ef1914b549e06b9d8e12dac5ddeeb4fe003a323</citedby><cites>FETCH-LOGICAL-c474t-f1dd8566afd6bf3447bf74602ef1914b549e06b9d8e12dac5ddeeb4fe003a323</cites><orcidid>0000-0002-0365-3053</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33433663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Theodorou, Christina M.</creatorcontrib><creatorcontrib>Jackson, Jordan E.</creatorcontrib><creatorcontrib>Rajasekar, Ganesh</creatorcontrib><creatorcontrib>Nuño, Miriam</creatorcontrib><creatorcontrib>Yamashiro, Kaeli J.</creatorcontrib><creatorcontrib>Farmer, Diana L.</creatorcontrib><creatorcontrib>Hirose, Shinjiro</creatorcontrib><creatorcontrib>Brown, Erin G.</creatorcontrib><title>Impact of prescription drug monitoring program mandate on postoperative opioid prescriptions in children</title><title>Pediatric surgery international</title><addtitle>Pediatr Surg Int</addtitle><addtitle>Pediatr Surg Int</addtitle><description>Purpose
Prescription drug monitoring programs (PDMPs) have been established to combat the opioid epidemic, but there is no data on their efficacy in children. We hypothesized that a statewide PDMP mandate would be associated with fewer opioid prescriptions in pediatric surgical patients.
Methods
Patients < 18 undergoing inguinal hernia repair, orchiopexy, orchiectomy, appendectomy, or cholecystectomy at a tertiary children’s hospital were included. The primary outcome, discharge opioid prescription, was compared for 10 months pre-PDMP (
n
= 158) to 10 months post-PDMP (
n
= 228). Interrupted time series analysis was performed to determine the effect of the PDMP on opioid prescribing.
Results
Over the 20-month study period, there was an overall decrease in the rate of opioid prescriptions per month (− 3.6% change,
p
< 0.001). On interrupted time series analysis, PDMP implementation was not associated with a significant decrease in the monthly rate of opioid prescriptions (1.27% change post-PDMP,
p
= 0.4). However, PDMP implementation was associated with a reduction in opioid prescriptions of greater than 5 days’ supply (− 2.7% per month,
p
= 0.03).
Conclusion
Opioid prescriptions declined in pediatric surgical patients over the study time period. State-wide PDMP implementation was associated with a reduction in postoperative opioid prescriptions of more than 5 days’ duration.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Narcotics</subject><subject>Original</subject><subject>Original Article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Postoperative period</subject><subject>Prescriptions</subject><subject>Surgery</subject><subject>Therapeutic drug monitoring</subject><subject>Time series</subject><issn>0179-0358</issn><issn>1437-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU1vFSEUhonR2Gv1D7gwk7hxM3r4GBg2Jqbxo0kTN90TZoB7aWYAgWnivy_XW6t14YqE8_DCy4PQawzvMYD4UADoSHsg0AMbGe_JE7TDjIpejpg-RTvAQvZAh_EMvSjlBgBGyuVzdEYpo5RzukOHyzXpuXbRdSnbMmefqo-hM3nbd2sMvsbsw74N4z7rtVt1MLrariEplhqTzbr627aRfPTmUUjpfOjmg19MtuEleub0Uuyr-_UcXX_5fH3xrb_6_vXy4tNVPzPBau-wMePAuXaGT44yJiYnGAdiHZaYTQOTFvgkzWgxMXoejLF2Ys62v9CU0HP08RSbtmm1ZrahZr2olP2q808VtVePJ8Ef1D7eqhEIZyBawLv7gBx_bLZUtfoy22XRwcatKMKEIBxLKhv69h_0Jm45tHaKDCAZBU6HRpETNedYSrbu4TEY1NGjOnlUzaP65VEda7z5u8bDkd_iGkBPQElHPzb_ufs_sXdjWqxk</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Theodorou, Christina M.</creator><creator>Jackson, Jordan E.</creator><creator>Rajasekar, Ganesh</creator><creator>Nuño, Miriam</creator><creator>Yamashiro, Kaeli J.</creator><creator>Farmer, Diana L.</creator><creator>Hirose, Shinjiro</creator><creator>Brown, Erin G.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0365-3053</orcidid></search><sort><creationdate>20210501</creationdate><title>Impact of prescription drug monitoring program mandate on postoperative opioid prescriptions in children</title><author>Theodorou, Christina M. ; Jackson, Jordan E. ; Rajasekar, Ganesh ; Nuño, Miriam ; Yamashiro, Kaeli J. ; Farmer, Diana L. ; Hirose, Shinjiro ; Brown, Erin G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-f1dd8566afd6bf3447bf74602ef1914b549e06b9d8e12dac5ddeeb4fe003a323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Narcotics</topic><topic>Original</topic><topic>Original Article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Postoperative period</topic><topic>Prescriptions</topic><topic>Surgery</topic><topic>Therapeutic drug monitoring</topic><topic>Time series</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Theodorou, Christina M.</creatorcontrib><creatorcontrib>Jackson, Jordan E.</creatorcontrib><creatorcontrib>Rajasekar, Ganesh</creatorcontrib><creatorcontrib>Nuño, Miriam</creatorcontrib><creatorcontrib>Yamashiro, Kaeli J.</creatorcontrib><creatorcontrib>Farmer, Diana L.</creatorcontrib><creatorcontrib>Hirose, Shinjiro</creatorcontrib><creatorcontrib>Brown, Erin G.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric surgery international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Theodorou, Christina M.</au><au>Jackson, Jordan E.</au><au>Rajasekar, Ganesh</au><au>Nuño, Miriam</au><au>Yamashiro, Kaeli J.</au><au>Farmer, Diana L.</au><au>Hirose, Shinjiro</au><au>Brown, Erin G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of prescription drug monitoring program mandate on postoperative opioid prescriptions in children</atitle><jtitle>Pediatric surgery international</jtitle><stitle>Pediatr Surg Int</stitle><addtitle>Pediatr Surg Int</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>37</volume><issue>5</issue><spage>659</spage><epage>665</epage><pages>659-665</pages><issn>0179-0358</issn><eissn>1437-9813</eissn><abstract>Purpose
Prescription drug monitoring programs (PDMPs) have been established to combat the opioid epidemic, but there is no data on their efficacy in children. We hypothesized that a statewide PDMP mandate would be associated with fewer opioid prescriptions in pediatric surgical patients.
Methods
Patients < 18 undergoing inguinal hernia repair, orchiopexy, orchiectomy, appendectomy, or cholecystectomy at a tertiary children’s hospital were included. The primary outcome, discharge opioid prescription, was compared for 10 months pre-PDMP (
n
= 158) to 10 months post-PDMP (
n
= 228). Interrupted time series analysis was performed to determine the effect of the PDMP on opioid prescribing.
Results
Over the 20-month study period, there was an overall decrease in the rate of opioid prescriptions per month (− 3.6% change,
p
< 0.001). On interrupted time series analysis, PDMP implementation was not associated with a significant decrease in the monthly rate of opioid prescriptions (1.27% change post-PDMP,
p
= 0.4). However, PDMP implementation was associated with a reduction in opioid prescriptions of greater than 5 days’ supply (− 2.7% per month,
p
= 0.03).
Conclusion
Opioid prescriptions declined in pediatric surgical patients over the study time period. State-wide PDMP implementation was associated with a reduction in postoperative opioid prescriptions of more than 5 days’ duration.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33433663</pmid><doi>10.1007/s00383-020-04846-2</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0365-3053</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0179-0358 |
| ispartof | Pediatric surgery international, 2021-05, Vol.37 (5), p.659-665 |
| issn | 0179-0358 1437-9813 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8026407 |
| source | Springer Nature |
| subjects | Medicine Medicine & Public Health Narcotics Original Original Article Pediatric Surgery Pediatrics Postoperative period Prescriptions Surgery Therapeutic drug monitoring Time series |
| title | Impact of prescription drug monitoring program mandate on postoperative opioid prescriptions in children |
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