Inverse association of mortality and body mass index in patients with left ventricular systolic dysfunction of both ischemic and non‐ischemic etiologies

Background Obesity is a worldwide epidemic that has been associated with poor outcomes. Previous studies have demonstrated an inverse relationship between body mass index (BMI) and outcomes, the 'obesity paradox', in several diseases. Hypothesis We sought to evaluate whether the obesity pa...

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Bibliographic Details
Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 2021-04, Vol.44 (4), p.495-500
Main Authors: Brazile, Tiffany, Mulukutla, Suresh, Thoma, Floyd, Estes, N. A. Mark, Jain, Sandeep, Saba, Samir
Format: Article
Language:English
Subjects:
Body mass index
Chronic obstructive pulmonary disease
Clinical Investigations
left ventricular systolic dysfunction
morbidity
Mortality
Obesity
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Summary:Background Obesity is a worldwide epidemic that has been associated with poor outcomes. Previous studies have demonstrated an inverse relationship between body mass index (BMI) and outcomes, the 'obesity paradox', in several diseases. Hypothesis We sought to evaluate whether the obesity paradox is present in patients with left ventricular systolic dysfunction (LVSD) of all etiologies, using all‐cause mortality as the primary endpoint and hospitalization as the secondary endpoint. Methods We conducted a retrospective cohort study of LVSD patients (n = 18 003) seen within the University of Pittsburgh Medical Center network between January 2011 and December 2017. Patients were divided into four BMI categories (underweight, normal weight, overweight, and obese) and stratified by left ventricular ejection fraction (LVEF):
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.23556