Evaluation of the retinal layers and microvasculature in patients with acromegaly: a case-control OCT angiography study

Background The aim of study was to evaluate the retinal layers and macular capillary network with OCTA in acromegaly patients, to compare with healthy population. Methods In this prospective, observational, and comparative study, 40 acromegaly patients and 40 healthy control participants were includ...

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Bibliographic Details
Published in:Eye (London) 2021-02, Vol.35 (2), p.523-527
Main Authors: Akay, Fahrettin, Akmaz, Berkay, Işik, Mehmed Uğur, Güven, Yusuf Ziya, Örük, Güzide Gonca
Format: Article
Language:English
Subjects:
692/308/409
692/699/2743
Acromegaly
Acromegaly - diagnostic imaging
Acuity
Angiography
Case-Control Studies
Fluorescein Angiography
Humans
Insulin-like growth factor I
Laboratory Medicine
Medical imaging
Medicine
Medicine & Public Health
Microvasculature
Microvessels - diagnostic imaging
Ophthalmology
Perfusion
Pharmaceutical Sciences/Technology
Prospective Studies
Retina
Retinal Vessels - diagnostic imaging
Surgery
Surgical Oncology
Tomography, Optical Coherence
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Summary:Background The aim of study was to evaluate the retinal layers and macular capillary network with OCTA in acromegaly patients, to compare with healthy population. Methods In this prospective, observational, and comparative study, 40 acromegaly patients and 40 healthy control participants were included. Serum IGF-1 levels and disease duration of all patients were noted. Macular layers and angiography scanning was performed with a Zeiss Cirrus 5000 OCTA system. Macular thickness, RNFL, and GC-IPL values were obtained. For central vessel and perfusion density, central 6 mm was obtained and was evaluated by dividing into three groups (inner, outer, full). FAZ parameters were evaluated dividing into three groups (area, perimeter, circularity index). Analysis of the data was performed with the SPSS for Windows. Results There was no significant difference between the patient group and the control group in terms of age, gender, best corrected visual acuity (BCVA), spherical equivalent (SE), intraocular pressure (IOP), and axial length (AL). The mean follow-up period after diagnosis was 11.0 ± 5.5 years. Central and mean macular thicknesses were also significantly higher in the acromegaly group ( p  
ISSN:0950-222X
1476-5454
DOI:10.1038/s41433-020-0884-2