Prospective deep phenotyping of choroideremia patients using multimodal structure-function approaches

Objective To investigate the retinal changes in choroideremia (CHM) patients to determine correlations between age, structure and function. Subjects/Methods Twenty-six eyes from 13 male CHM patients were included in this prospective longitudinal study. Participants were divided into

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Bibliographic Details
Published in:Eye (London) 2021-03, Vol.35 (3), p.838-852
Main Authors: Hagag, Ahmed M., Mitsios, Andreas, Narayan, Akshay, Abbouda, Alessandro, Webster, Andrew R., Dubis, Adam M., Moosajee, Mariya
Format: Article
Language:English
Subjects:
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Acuity
Age
Age composition
Angiography
Choroid
Choroideremia
Clinical trials
Electroretinograms
Fluorescein Angiography
Humans
Laboratory Medicine
Longitudinal Studies
Male
Medical imaging
Medicine
Medicine & Public Health
Mutation
Ophthalmology
Patients
Pharmaceutical Sciences/Technology
Phenotyping
Photoreceptors
Prospective Studies
Sensitivity analysis
Structure-function relationships
Surgery
Surgical Oncology
Tomography, Optical Coherence
Visual discrimination
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Description
Summary:Objective To investigate the retinal changes in choroideremia (CHM) patients to determine correlations between age, structure and function. Subjects/Methods Twenty-six eyes from 13 male CHM patients were included in this prospective longitudinal study. Participants were divided into
ISSN:0950-222X
1476-5454
DOI:10.1038/s41433-020-0974-1