Association of impaired endothelial glycocalyx with arterial stiffness, coronary microcirculatory dysfunction, and abnormal myocardial deformation in untreated hypertensives

We investigated the association of endothelial glycocalyx damage with arterial stiffness, impairment of coronary microcirculatory function, and LV myocardial deformation in 320 untreated hypertensives and 160 controls. We measured perfused boundary region (PBR) of the sublingual microvessels, a mark...

Full description

Saved in:
Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2018-04, Vol.20 (4), p.672-679
Main Authors: Ikonomidis, Ignatios, Voumvourakis, Astrinos, Makavos, George, Triantafyllidi, Helen, Pavlidis, George, Katogiannis, Konstantinos, Benas, Dimitris, Vlastos, Dimitris, Trivilou, Paraskevi, Varoudi, Maria, Parissis, John, Iliodromitis, Efstathios, Lekakis, John
Format: Article
Language:English
Subjects:
Adult
Arterial Stiffness
Case-Control Studies
Coronary Vessels - physiopathology
endothelial glycocalyx
Female
Glycocalyx - metabolism
Heart Diseases - physiopathology
Humans
Hypertension - complications
Hypertension - physiopathology
longitudinal strain
Male
Microcirculation
Middle Aged
Original Paper
pulse wave velocity
Vascular Stiffness
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the association of endothelial glycocalyx damage with arterial stiffness, impairment of coronary microcirculatory function, and LV myocardial deformation in 320 untreated hypertensives and 160 controls. We measured perfused boundary region (PBR) of the sublingual microvessels, a marker inversely related with glycocalyx thickness, coronary flow reserve (CFR), and Global Longitudinal strain (GLS) by echocardiography, pulse wave velocity (PWV), and central systolic blood pressure (cSBP). Hypertensives had higher PBR, PWV cSBP, and lower CFR and GLS than controls (P 
ISSN:1524-6175
1751-7176
DOI:10.1111/jch.13236