Reference intervals and percentiles for carotid‐femoral pulse wave velocity in a healthy population aged between 9 and 87 years

There is little information regarding age‐related reference intervals (RIs) of carotid‐femoral pulse wave velocity (cfPWV) for large healthy populations in South America. The aims of this study were to determine cfPWV RIs and percentiles in a cohort of healthy children, adolescents, and adults and t...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2018-04, Vol.20 (4), p.659-671
Main Authors: Diaz, Alejandro, Zócalo, Yanina, Bia, Daniel, Wray, Sandra, Fischer, Edmundo Cabrera
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Arterial Stiffness
Carotid Arteries - physiology
Child
epidemiology
Female
Femoral Artery - physiology
Healthy Volunteers
Humans
Male
Middle Aged
Original Paper
Pulse Wave Analysis - standards
pulse wave velocity
reference intervals
Reference Values
South America
Young Adult
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Summary:There is little information regarding age‐related reference intervals (RIs) of carotid‐femoral pulse wave velocity (cfPWV) for large healthy populations in South America. The aims of this study were to determine cfPWV RIs and percentiles in a cohort of healthy children, adolescents, and adults and to generate year‐to‐year percentile curves and body‐height percentile curves for children and adolescents. cfPWV was measured in 1722 healthy participants with no cardiovascular risk factors (9–87 years, 60% men). First, RIs were evaluated for males and females through correlation and covariate analysis. Then, mean and standard deviation age‐related equations were obtained for cfPWV using parametric regression methods based on fractional polynomials and age‐specific (year‐to‐year) percentile curves that were defined using the standard normal distribution. Age‐specific first, 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, 95th, 97.5th, and 99th percentile curves were calculated. Finally, height‐related cfPWV percentile curves for children and adolescents (
ISSN:1524-6175
1751-7176
DOI:10.1111/jch.13251