Diet‐independent relevance of serum uric acid for blood pressure in a representative population sample

A direct relationship between serum uric acid and blood pressure (BP) has been reported, but the possible confounding impact of diet on this association is unclear. The authors performed a cross‐sectional analysis in the representative German Health Interview and Examination Survey for Adults (n=678...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2017-10, Vol.19 (10), p.1042-1050
Main Authors: Krupp, Danika, Esche, Jonas, Mensink, Gert BM, Neuhauser, Hannelore K, Remer, Thomas
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Blood Pressure - physiology
Cross-Sectional Studies
diet
Diet - adverse effects
Dose-Response Relationship, Drug
Female
Germany
Germany - epidemiology
Humans
hypertension
Hypertension - blood
Hypertension - complications
Hypertension - epidemiology
Hypertension - physiopathology
Hyperuricemia - complications
Hyperuricemia - epidemiology
Male
Middle Aged
Original Paper
Prevalence
Risk Factors
Uric Acid
Uric Acid - blood
Young Adult
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Summary:A direct relationship between serum uric acid and blood pressure (BP) has been reported, but the possible confounding impact of diet on this association is unclear. The authors performed a cross‐sectional analysis in the representative German Health Interview and Examination Survey for Adults (n=6788, aged 18–79 years). In adjusted regression models considering dietary factors, each 1‐mg/dL higher uric acid value was associated with a 1.10‐mm Hg (P=.0002) and a 0.60‐mm Hg (P=.04) higher systolic BP among participants younger than 50 years and participants 50 years and older, respectively. For diastolic BP, uric acid was a significant predictor (β=0.71 mm Hg, P=.0001) among participants younger than 50 years and for participants 50 years and older without antihypertensive treatment. Adjusted odds ratios of hypertension for participants with hyperuricemia were broadly similar in younger (odds ratio, 1.71; P=.02) and older (odds ratio, 1.81; P=.0003) participants. Uric acid is a significant predictor of systolic BP and hypertension prevalence in the general adult population in Germany independently of several known dietary BP influences.
ISSN:1524-6175
1751-7176
DOI:10.1111/jch.13046