Ambulatory Arterial Stiffness Index Is Not Associated With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Lacunar Stroke Patients

Ambulatory arterial stiffness index (AASI) is associated with microvascular damage in other organs, but the association with microvascular brain damage is unknown. The association of AASI with magnetic resonance imaging (MRI) markers of cerebral small vessel disease in 143 patients with lacunar stro...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2015-05, Vol.17 (5), p.352-356
Main Authors: Klarenbeek, Pim, Oostenbrugge, Robert J., Staals, Julie
Format: Article
Language:English
Subjects:
Aged
Blood Pressure Monitoring, Ambulatory - methods
Female
Humans
Hypertension - pathology
Hypertension - physiopathology
Logistic Models
Magnetic Resonance Imaging - methods
Male
Middle Aged
Monitoring, Ambulatory - methods
Original Paper
Prospective Studies
Pulse Wave Analysis - methods
Risk Factors
Stroke, Lacunar - diagnosis
Stroke, Lacunar - metabolism
Stroke, Lacunar - pathology
Vascular Stiffness - physiology
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Summary:Ambulatory arterial stiffness index (AASI) is associated with microvascular damage in other organs, but the association with microvascular brain damage is unknown. The association of AASI with magnetic resonance imaging (MRI) markers of cerebral small vessel disease in 143 patients with lacunar stroke was investigated. We performed 24‐hour ambulatory blood pressure monitoring and scored the presence of lacunes, white matter hyperintensities, perivascular spaces, and cerebral microbleeds on brain MRI. In logistic regression analyses, AASI was associated with white matter hyperintensities, but, after adjustment for age and sex, this association lost significance. AASI was not associated with lacunes, microbleeds, or perivascular spaces. Systolic and diastolic 24‐hour blood pressure values were associated with lacunes, perivascular spaces, and microbleeds independent of age and sex. Despite its significance and growing interest as a possible prognostic and therapeutic target in (micro)vascular diseases, AASI seems to have no added value over standard 24‐hour blood pressure in cerebral small vessel disease.
ISSN:1524-6175
1751-7176
1751-7176
DOI:10.1111/jch.12504