Minoxidil for Treatment of Resistant Hypertension in Chronic Kidney Disease––A Retrospective Cohort Analysis

Resistant hypertension is still a challenge and reserve antihypertensive agents are often necessary to achieve blood pressure control. One reserve antihypertensive is minoxidil, a direct vasodilator that is known for its strong blood pressure–lowering effect, but contemporary studies are sparse. The...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2016-11, Vol.18 (11), p.1162-1167
Main Authors: Mundt, Heiko M., Matenaer, Matthias, Lammert, Alexander, Göttmann, Uwe, Krämer, Bernhard K., Birck, Rainer, Benck, Urs
Format: Article
Language:English
Subjects:
Aged
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - therapeutic use
Drug Therapy, Combination
Female
Humans
Hypertension - drug therapy
Inpatients
Male
Middle Aged
Minoxidil - administration & dosage
Minoxidil - therapeutic use
Original Paper
Renal Insufficiency, Chronic - pathology
Retrospective Studies
Treatment Outcome
Treatment Resistant Hypertension
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Summary:Resistant hypertension is still a challenge and reserve antihypertensive agents are often necessary to achieve blood pressure control. One reserve antihypertensive is minoxidil, a direct vasodilator that is known for its strong blood pressure–lowering effect, but contemporary studies are sparse. The authors retrospectively analyzed 54 inpatients with uncontrolled hypertension despite the combined use of current antihypertensive agents. To investigate the effect of minoxidil when added to other antihypertensive agents, blood pressure was evaluated at the time minoxidil treatment was initiated and at discharge. Minoxidil treatment was associated with a significant reduction in blood pressure from 162.4±15.1/83.2±12.7 mm Hg to 135.8±12.2/72.8±6.9 mm Hg (P
ISSN:1524-6175
1751-7176
1751-7176
DOI:10.1111/jch.12847