Cerebral Blood Flow and Cognitive Function in Patients With Metabolic Syndrome: Effect of Antihypertensive Therapy

The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2014-12, Vol.16 (12), p.900-906
Main Authors: Efimova, Irina, Efimova, Natalya, Lishmanov, Yuri
Format: Article
Language:English
Subjects:
Adult
Antihypertensive Agents - therapeutic use
Brain - diagnostic imaging
Brain - physiopathology
Cerebrovascular Circulation - drug effects
Cerebrovascular Circulation - physiology
Cognition - drug effects
Female
Humans
Male
Metabolic Syndrome - diagnostic imaging
Metabolic Syndrome - drug therapy
Metabolic Syndrome - physiopathology
Middle Aged
Neuropsychological Tests
Original Paper
Original Papers
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
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Summary:The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single‐photon emission computed tomography with technetium‐99m hexamethylpropyleneamine oxime and comprehensive neuropsychological testing before and after 6‐month antihypertensive combination therapy. All patients with MetS showed lower rCBF values in all regions of the brain compared with the control group. Their parameters of attention, immediate visual memory, and mentation were lower by 25%, 22%, and 13% compared with the control group, respectively. Six‐month antihypertensive combination therapy increased cerebral perfusion and improved attention, mentation, and visual memory in MetS patients.
ISSN:1524-6175
1751-7176
1751-7176
DOI:10.1111/jch.12435