Visceral adiposity, subcutaneous adiposity, and severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis

Body mass index (BMI) has previously been shown to increase mortality and disease severity in patients with COVID-19, but the pooled effect estimate was heterogeneous. Although BMI is widely used as an indicator, it cannot distinguish visceral from subcutaneous fat. This systematic review and meta-a...

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Bibliographic Details
Published in:Clinical nutrition ESPEN 2021-06, Vol.43, p.163-168
Main Authors: Pranata, Raymond, Lim, Michael Anthonius, Huang, Ian, Yonas, Emir, Henrina, Joshua, Vania, Rachel, Lukito, Antonia Anna, Nasution, Sally Aman, Alwi, Idrus, Siswanto, Bambang Budi
Format: Article
Language:English
Subjects:
Adiposity
Coronavirus
Meta-Analysis
Obesity
Visceral fat
Visceral fat area
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Summary:Body mass index (BMI) has previously been shown to increase mortality and disease severity in patients with COVID-19, but the pooled effect estimate was heterogeneous. Although BMI is widely used as an indicator, it cannot distinguish visceral from subcutaneous fat. This systematic review and meta-analysis aimed to investigate the association between visceral adiposity, subcutaneous fat, and severe COVID-19. We performed a systematic literature search using the databases: PubMed, Embase, and EuropePMC. Data on visceral fat area (VTA), subcutaneous fat area (SFA), and total fat area (TFA) were collected. The outcome of interest was severe COVID-19. We used a REML random-effects model to pool the mean differences and odds ratio (OR). There were 5 studies comprising of 539 patients. Patients with severe COVID-19 have a higher VTA (mean difference 41.7 cm2 [27.0, 56.4], p 
ISSN:2405-4577
2405-4577
DOI:10.1016/j.clnesp.2021.04.001