Potentially inappropriate prescribing in older hospitalized Dutch patients according to the STOPP/START criteria v2: a longitudinal study

• Published in: European journal of clinical pharmacology 2021-05, Vol.77 (5), p.777-785
• Main Authors: Damoiseaux-Volman, Birgit A., Medlock, Stephanie, Raven, Kimmy, Sent, Danielle, Romijn, Johannes A., van der Velde, Nathalie, Abu-Hanna, Ameen
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Electronic medical records; Longitudinal studies; Patients; Pharmacoepidemiology and Prescription; Pharmacology/Toxicology
• ISSN: 0031-6970; 1432-1041
• DOI: 10.1007/s00228-020-03052-2

Purpose To investigate prevalence, independent associations, and variation over time of potentially inappropriate prescriptions in a population of older hospitalized patients. Methods A longitudinal study using a large dataset of hospital admissions of older patients (≥ 70 years) based on an electronic health records cohort including data from 2015 to 2019. Potentially inappropriate medication (PIM) and potential prescribing omission (PPO) prevalence during hospital stay were identified based on the Dutch STOPP/START criteria v2. Univariate and multivariate logistic regression were used for analyzing associations and trends over time. Results The data included 16,687 admissions. Of all admissions, 56% had ≥ 1 PIM and 58% had ≥ 1 PPO. Gender, age, number of medications, number of diagnoses, Charlson score, and length of stay were independently associated with both PIMs and PPOs. Additionally, number of departments and number of prescribing specialties were independently associated with PIMs. Over the years, the PIM prevalence did not change (OR = 1.00, p  = .95), whereas PPO prevalence increased (OR = 1.08, p