Chikungunya infection in pregnancy – reassuring maternal and perinatal outcomes: a retrospective observational study

• Published in: BJOG : an international journal of obstetrics and gynaecology 2021-05, Vol.128 (6), p.1077-1086
• Main Authors: Foeller, ME, Nosrat, C, Krystosik, A, Noel, T, Gérardin, P, Cudjoe, N, Mapp‐Alexander, V, Mitchell, G, Macpherson, C, Waechter, R, LaBeaud, AD
• Format: Article
• Language: English
• Subjects: Adult; Birth; Cesarean section; Chikungunya; Chikungunya Fever - diagnosis; Chikungunya Fever - epidemiology; Chikungunya Fever - physiopathology; Chikungunya Fever - transmission; Chikungunya virus; Chikungunya virus - isolation & purification; Clinical outcomes; Complications; Delivery, Obstetric - adverse effects; Delivery, Obstetric - methods; Delivery, Obstetric - statistics & numerical data; Disease Outbreaks - statistics & numerical data; Epidemiology; Female; Fetal Distress - diagnosis; Fetal Distress - etiology; Fetuses; Grenada - epidemiology; Humans; Infant, Newborn; Infants; Infectious Disease Transmission, Vertical - statistics & numerical data; Life Sciences; Maternal & child health; Morbidity; mother‐to‐child‐transmission; neonatal outcomes; Neonates; Newborn babies; Observational studies; Outbreaks; Pain; Parasitic diseases; Placenta; Population studies; Pregnancy; Pregnancy complications; Pregnancy Complications, Infectious - diagnosis; Pregnancy Complications, Infectious - epidemiology; Pregnancy Complications, Infectious - physiopathology; Pregnancy Outcome - epidemiology; pregnancy outcomes; Serologic Tests - methods; Severity of Illness Index; Vagina; vertical transmission; Viral infections
• ISSN: 1470-0328; 1471-0528
• DOI: 10.1111/1471-0528.16562

Objective To evaluate pregnancy and neonatal outcomes, disease severity, and mother‐to‐child transmission of pregnant women with Chikungunya infection (CHIKV). Design Retrospective observational study. Setting Grenada. Population Women who gave birth during a Chikungunya outbreak between January 2014 and September 2015 were eligible. Methods This descriptive study investigated 731 mother‐infant pairs who gave birth during a CHIKV outbreak. Women and infants underwent serological testing for CHIKV by ELISA. Main outcome measures Primary outcomes: composite pregnancy complication (abruption, vaginal bleeding, preterm labour/cervical incompetence, cesarean delivery for fetal distress/abruption/placental abnormality or delivery for fetal distress) and composite neonatal morbidity. Results Of 416 mother‐infant pairs, 150 (36%) had CHIKV during pregnancy, 135 (33%) had never had CHIKV, and 131 (31%) had CHIKV outside of pregnancy. Mean duration of joint pain was shorter among women infected during pregnancy (μ = 898 days, σ = 277 days) compared with infections outside of pregnancy (μ = 1064 days, σ = 244 days) (P